AI Article Synopsis
- The study aimed to investigate the presence of IL-1beta and MMP-8 in the saliva of patients with different types of periodontitis and explore their potential as biomarkers for the disease.
- Researchers collected saliva samples from 80 individuals, including patients with generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy controls, measuring levels of IL-1beta and MMP-8.
- Results showed no significant difference in IL-1beta levels across the groups, but MMP-8 levels were significantly higher in both periodontitis groups compared to controls, suggesting MMP-8 could serve as a potential biomarker while more research on IL-1beta is needed.
Article Abstract
Purpose: To detect the role of IL-1beta and MMP-8 by ELISA in whole unstimulated saliva of patients with different type of periodontitis and to determine whether they are possible specific biomarkers of periodontitis.
Methods: A total of 80 saliva samples were collected from 28 GCP patients, 28 GAgP patients and 24 healthy subjects. The levels of IL-1beta and MMP-8 were respectively measured by ELISA kits. The data were analysed statistically with one-way ANOVA.
Results: The mean salivary levels of IL-1beta in GCP group,GAgP group and control group were 144.40 pg/ml+/-150.70 pg/ml+/-72.56 pg/ml+/-69.36 pg/ml and 65.96 pg/ml+/-71.18 pg/ml respectively, There was no significance difference between the three groups (P>0.05); GCP and GAgP groups presented significantly elevated salivary levels of MMP-8 than that of the control group, which was (576.89+/-559.24) ng/ml, (420.93+/-533.73)ng/ml and (151.49+/-216.38) ng/ml respectively (P<0.05), while there was no significant difference between GCP and GAgP group (P>0.05).
Conclusion: Salivary levels of MMP-8 may be a biomarker for diagnosis for periodontitis while IL-1beta needs to be further testified.
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