Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/vr.160.22.770 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Body Size on Plasma and Tissue Pharmacokinetics of Danofloxacin in Rainbow Trout ().
Animals (Basel)
November 2024
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Hatay Mustafa Kemal, Hatay 31060, Türkiye.
Article Synopsis
- Danofloxacin, a fluoroquinolone antibiotic, is effective against bacterial infections in fish, but its pharmacokinetics vary based on fish size, impacting its medicinal effectiveness.!* -
- A study conducted on rainbow trout demonstrated that larger fish have higher plasma concentrations and overall drug efficacy of danofloxacin compared to smaller fish, with measurements taken after oral administration.!* -
- While larger fish show increased therapeutic efficacy, their higher drug concentrations in tissues raise concerns about potential residue and withdrawal time for safe consumption.!*
Concentration-resistance relationship and PK/PD evaluation of danofloxacin against emergence of resistant Pasteurella multocida in an in vitro dynamic model.
J Appl Microbiol
July 2024
Guangdong Laboratory for Lingnan Modern Agriculture, National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China.
Aims: This study aimed to assess the pharmacokinetic/pharmacodynamic (PK/PD) targets of danofloxacin to minimize the risk of selecting resistant Pasteurella multocida mutants and to identify the mechanisms underlying their resistance in an in vitro dynamic model, attaining the optimum dosing regimen of danofloxacin to improve its clinical efficacy based on the mutant selection window (MSW) hypothesis.
Methods And Results: Danofloxacin at seven dosing regimens and 5 days of treatment were simulated to quantify the bactericidal kinetics and enrichment of resistant mutants upon continuous antibiotic exposure. The magnitudes of PK/PD targets associated with different efficacies were determined in the model.
The activity of danofloxacin plus ceftiofur combination: implications for antimicrobial efficacy and resistance prevention.
Vet Res Forum
June 2022
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Uludag University, Nilufer, Turkiye.
Due to the high prevalence of multi-drug resistant bacteria, combination therapy is an efficient choice for treatment of infections caused by highly resistant strains. In this study, the efficacy of ceftiofur plus danofloxacin combination was investigated against resistant . The interaction between the two drugs was determined by checkerboard tests and time-kill assays.
View Article and Find Full Text PDFPopulation Pharmacokinetics of Danofloxacin in Yellow River Carp () After One Single Oral Dose.
Front Vet Sci
April 2022
Department of Veterinary Pharmacology, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China.
Article Synopsis
- This study investigated how danofloxacin is processed in Yellow River carp after a single oral dose of 10 mg/kg body weight, focusing on its population pharmacokinetics.
- Researchers collected plasma samples at various time points to measure drug concentrations using HPLC, finding that danofloxacin could be detected for up to 144 hours post-administration.
- The population pharmacokinetic model developed highlighted the variability in absorption, distribution, and clearance, suggesting that the current dosing effectively inhibits certain pathogens, but further research is needed to confirm its antibacterial efficacy.
In-vitro antibiotic resistance phenotypes of respiratory and enteric bacterial isolates from weaned dairy heifers in California.
PLoS One
January 2022
Department of Veterinary Medicine and Epidemiology, University of California, School of Veterinary Medicine, Davis, California, United States of America.
Antimicrobial drug (AMD) use for bovine respiratory disease (BRD) continues to be concerning for development of antimicrobial resistance (AMR) in respiratory and enteric bacteria of cattle. This study aimed to provide data regarding AMR in respiratory isolates, and identify relationships between respiratory and enteric AMD susceptibility, in weaned dairy heifers. A cross-sectional study was performed between June of 2019 and February 2020, on 6 calf rearing facilities in California.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!