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Butorphanol Alleviates Hypoxia/Reoxygenation-Induced Myocardial Injury by Activating Wnt/β-Catenin Signal Pathway.
J Appl Toxicol
December 2024
Department of Anesthesiology, First Hospital Affiliated of Jinzhou Medical University, Jinzhou, Liaoning, China.
Ischemic heart disease remains a global health problem with high morbidity and mortality. Butorphanol, as a novel opioid, has been discovered with its cardioprotective properties. The purpose of this study was to explore that butorphanol can alleviate hypoxia/reoxygenation (H/R)-induced myocardial injury by activating the Wnt/β-catenin signal pathway.
View Article and Find Full Text PDFCardioprotective Effect of Selective μ-Opioid Receptor Agonist Endomorphin-1 in Cardiac Reperfusion In Vivo and In Vitro.
Bull Exp Biol Med
November 2024
Cardiology Research Institute, Tomsk National Research Medical Center, Tomsk, Russia.
The effect of the selective μ-opioid receptor agonist endomorphin-1 in reperfusion injury in male Wistar rats was studied in vivo and in vitro. The in vivo experiment included coronary artery occlusion (45 min) and reperfusion (120 min); in in vitro experiments, 45-min global ischemia of the isolated rat heart was followed by 30-min reperfusion. Endomorphin-1 was administered intravenously 5 min before in vivo reperfusion (at a dose 50 μg/kg) or added to the perfusion solution at the onset of reperfusion of the isolated heart (in a concentration of 152 nmol/liter).
View Article and Find Full Text PDFThe activated caveolin-3/μ-opioid receptor complex drives morphine-induced rescue therapy in failing hearts.
Br J Pharmacol
February 2025
Department of Anesthesiology, the Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Article Synopsis
- Opioid analgesics, like morphine, can help protect the heart from damage caused by ischaemia/reperfusion injury in patients with chronic heart failure, but the exact mechanisms behind this effect are not yet clear.
- The study investigates the interaction between caveolin-3 (Cav3) and μ opioid receptors in heart tissues and examines how this interaction contributes to cardioprotection when using morphine.
- Results show that both Cav3 and μ receptors are more abundant in failing hearts and disruptors of Cav3 inhibit morphine’s protective effects, indicating that the Cav3/μ receptor complex could be a valuable target for treating heart failure and related ischaemic injuries.
Ceftriaxone and MC-100093 mitigate fentanyl-induced cardiac injury in mice: Preclinical investigation of its underlying molecular mechanisms.
Saudi Pharm J
September 2024
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Drug addiction is considered a worldwide concern and one of the most prevailing causes of death globally. Opioids are highly addictive drugs, and one of the most common opioids that is frequently used clinically is fentanyl. The potential harmful effects of chronic exposure to opioids on the heart are still to be elucidated.
View Article and Find Full Text PDFTargeting OGF/OGFR signal to mitigate doxorubicin-induced cardiotoxicity.
Free Radic Biol Med
October 2024
National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Fuwai Hospital of Zhengzhou University, Fuwai Central China Cardiovascular Hospital & Central China Branch of National Center for Cardiovascular Diseases, Zhengzhou, Henan, 451464, China; Zhengzhou Key Laboratory of Cardiovascular Aging, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, 451464, China; Henan Key Laboratory of Chronic Disease Management, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan, 451464, China. Electronic address:
Enkephalins are reportedly correlated with heart function. However, their regulation in the heart remains unexplored. This study revealed a substantial increase in circulating levels of opioid growth factor (OGF) (also known as methionine enkephalin) and myocardial expression levels of both OGF and its receptor (OGFR) in subjects treated with doxorubicin (Dox).
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