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Photochemical tissue bonding: a promising technique for peripheral nerve repair. | LitMetric

AI Article Synopsis

  • Photochemical tissue bonding (PTB) is a new method for repairing tissues using light and a dye to enhance protein connections, particularly in thin, collagen-rich tissues like the epineurium.
  • In a study on rats with sciatic nerve injuries, four different repair techniques were tested, including the traditional suture and PTB methods, and functional recovery was tracked over 90 days.
  • Results showed that PTB achieved similar healing outcomes as traditional methods, suggesting it could be a viable option for peripheral nerve repair with more research needed for further improvement.

Article Abstract

Background: Photochemical tissue bonding (PTB) is a novel tissue repair technique that uses visible light and a photosensitizing dye to crosslink proteins on tissue surfaces. This technique has been successfully demonstrated in a number of tissue repair models. An ideal nerve repair technique would be atraumatic and avoid placement of foreign bodies at the repair site. The epineurium is suited to photochemical repair as it is thin, translucent and has a relatively high collagen content. This study was designed to determine if PTB could be successfully applied in a peripheral nerve repair model.

Material And Methods: Forty Sprague Dawley rats underwent transection of the sciatic nerve. Animals were then randomized to four treatment groups; epineurial suture repair, epineurial cuff with PTB, epineurial cuff alone, and no repair. Functional recovery was assessed at 10 day intervals using walking track analysis and sciatic function index calculations. At 90 days postoperatively animals were sacrificed and sciatic nerves harvested for histology and histomorphometry.

Results: Functional recovery in the suture repair and epineural cuff with PTB groups were not significantly different (-70.6 +/- 17.8 versus -76.9 +/- 10.3, P = 0.64) at 90 days postrepair. Histology showed good axonal regeneration with all repair techniques. Histomorphometric analysis found no significant difference between the repair groups.

Conclusions: This study illustrates that peripheral nerves can be successfully repaired using a photochemical tissue bonding technique with results similar to those achieved with the current gold standard. With further development and refinement PTB may prove a useful tool in peripheral nerve repair.

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Source
http://dx.doi.org/10.1016/j.jss.2007.01.028DOI Listing

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