The pI50 index and separation coefficients of chosen 3-N,N-diethylaminophenyl-N',N'-dialkylcarbamates were determined. Index pL50 (pI50 = negative logarithm of molar concentration of inhibitor inhibiting the enzyme activity by 50%) describes the effectiveness of the inhibitor. The rate of ability of the inhibitor to pass the blood-brain barrier is usually described by the separation coefficient in a system n-octanol/water (K(ow)). Obtained results were compared with pL50 and K(ow) of Exelon, the commercially used drug against the Alzheimer's disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1515/znc-2007-3-423 | DOI Listing |
Publication Analysis
Top Keywords
inhibition cholinesterase
4
cholinesterase dialkylcarbamates
4
dialkylcarbamates pi50
4
pi50 separation
4
separation coefficients
4
coefficients chosen
4
chosen 3-nn-diethylaminophenyl-n'n'-dialkylcarbamates
4
3-nn-diethylaminophenyl-n'n'-dialkylcarbamates determined
4
determined pl50
4
pl50 pi50
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!