The identification of a potent series of IKK-beta selective inhibitors based on an imidazothienopyrazine template and the oral efficacy of one such analog (22j) in the LPS-induced TNF-alpha release mouse model are described.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2007.05.031 | DOI Listing |
Publication Analysis
Top Keywords
synthesis structure-activity
4
structure-activity relationship
4
relationship imidazo12-athieno32-epyrazines
4
imidazo12-athieno32-epyrazines ikk-beta
4
ikk-beta inhibitors
4
inhibitors identification
4
identification potent
4
potent series
4
series ikk-beta
4
ikk-beta selective
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!