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- Mice without matrix metalloproteinase-3 (MMP-3) showed less injury compared to normal mice when exposed to IgG-containing immune complexes in the lungs and peritoneum.
- *These MMP-3 deficient mice also experienced reduced lung injury when treated with the cytokine macrophage inhibitory protein-2 (MIP-2), indicating MMP-3's role in inflammation.
- *The study found that tissue injury correlated with the presence of anti-laminin 111 material and neutrophil influx in the fluid from the lungs and peritoneum, highlighting MMP-3 as significant in acute inflammatory damage.*
Article Abstract
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly less injury than their normal counterparts following the formation of IgG-containing immune complexes in the alveolar wall or in the wall of the peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between tissue injury (evidenced histologically) and accumulation of anti-laminin 111 immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage (PL) fluid. There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062514 | PMC |
| http://dx.doi.org/10.1016/j.yexmp.2007.04.003 | DOI Listing |
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