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Cellular and Intravital Nucleus Imaging by a D-π-A Type of Red-Emitting Two-Photon Fluorescent Probe.
Anal Chem
December 2024
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, 222 Tianshui Street S., Lanzhou, Gansu 730000, China.
The advancement in fluorescent probe technology for visualizing nuclear morphology and nucleic acid distribution in live cells and has attracted considerable interest within the biomedical research community, as it offers invaluable insights into cellular dynamics across various physiological and pathological contexts. In this study, we present a novel two-photon nucleus-imaging fluorescent probe called Nu-red, which is a typical donor(D)-π-acceptor(A) rotor composed of the donor (dihydroquinoline) and acceptor (pyridiniumylpentadienitrile) parts linked by a single bond. This probe offers several advantages, including long-wavelength excitation and emission (λ/λ = 610/664 nm), favorable quantum yields (1.
View Article and Find Full Text PDFPerivascular Neutrophil Extracellular Traps Exacerbate Microvasospasm After Experimental Subarachnoid Hemorrhage.
Stroke
December 2024
Department of Molecular Neuroscience (R.N., T.I., N.S., T.Y.), Graduate School of Medicine, Osaka University, Suita, Japan.
Article Synopsis
- Subarachnoid hemorrhage (SAH) can lead to cerebral ischemia, and recent research suggests that microvasospasm, influenced by perivascular inflammation, plays a role in this condition.
- A mouse model with intravital 2-photon imaging was used to study vascular and perivascular changes following SAH, revealing that neutrophils and neutrophil extracellular traps (NETs) contribute to the development of microvasospasms.
- The findings indicate that targeting perivascular NETs could be a potential new treatment approach for mitigating microvasospasm-related issues in SAH.
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model.
Front Oncol
October 2024
Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, United States.
Article Synopsis
- There is a need for therapies to address bone marrow dysfunction and organ toxicity following myeloablative injury during bone marrow transplantation (BMT), associated with damage to the vascular endothelium and other organs.* -
- The study aimed to assess the effects of the thrombopoietin mimetic drug JNJ-26366821 (TPOm) on the recovery of bone marrow vascularity in mice undergoing BMT after receiving radiation conditioning.* -
- Results indicated that while donor chimerism remained similar in TPOm and control-treated mice, the treatment enhanced bone marrow vasculature regeneration, showing dose-dependent improvements in microvascular density and other vascular metrics on day 14 post-BMT.*
[Issues of morphological diagnosis and pathogenesis of tuberculosis].
Arkh Patol
October 2024
Moscow Research and Clinical Center for TB Control, Moscow, Russia.
Tuberculosis remains a serious global problem of our time. The epidemiological situation regarding tuberculosis in the Russian Federation and in Moscow is quite favorable, however, many manifestations of diseases and morphological changes in tuberculosis require a serious approach to the timely diagnosis of the disease, especially intravital morphological verification of the process. The article outlines the main aspects of the pathogenesis of tuberculosis, including deep immunosuppression associated with HIV.
View Article and Find Full Text PDFLow-cost Polyethylene Terephthalate Lamination Microfluidics Designs for Multiplexed Zebrafish Imaging.
J Vis Exp
September 2024
Department of Biological Sciences, Purdue University;
Zebrafish embryos are transparent and thus uniquely suited for noninvasive intravital imaging of fundamental processes, such as wound healing and immune cell migration. Microfluidic devices are used for entrapment to support long-term imaging of multicellular organisms, including zebrafish. However, the fabrication of these devices using soft lithography requires specialized facilities and competency in 3D printing, which may not be accessible to every lab.
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