AI Article Synopsis
- Certain MHC class I alleles, like Mamu-B*08 in rhesus macaques, play a crucial role in controlling HIV and SIV replication.
- In a study of 196 SIV-infected macaques, 38% of elite controllers had the Mamu-B*08 allele, compared to only 3% of progressors.
- Mamu-B*08 was linked to a significant reduction in viral levels during chronic infection, suggesting it could help us understand immune responses in human elite controllers.
Article Abstract
Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV(mac)239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951344 | PMC |
| http://dx.doi.org/10.1128/JVI.00895-07 | DOI Listing |
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