AI Article Synopsis
- The study investigates the relationship between plasma osteopontin (OPN) levels and cholesterol metabolites in individuals with normal to mildly elevated cholesterol levels.
- OPN levels showed a significant negative correlation with muscle lathosterol and its ratio to cholesterol, especially in men, while this correlation was not found in women.
- The findings suggest a potential link between OPN and cholesterol metabolism, indicating that OPN may play a role in atherosclerosis development.
Article Abstract
Objective: Atherosclerotic lesions are characterized by an accumulation of inflammatory cells and lipids. Osteopontin (OPN) is a cell-binding phosphoprotein, and it seems to promote the development of atherosclerosis. The purpose of our study was to find out whether plasma levels of OPN are associated with cholesterol metabolites in plasma or tissues.
Methods And Results: Forty-three normal or mildly hypercholesterolaemic subjects, aged 31 to 69, were studied. The plasma level of OPN correlated negatively with muscle lathosterol (r = -0.52, P < 0.0001) and with the muscle lathosterol to muscle cholesterol ratio (r = -0.48, P = 0.001). Lathosterol concentrations in muscle (P = 0.003) and in relation to cholesterol (P = 0.005) were also significantly different among the OPN tertiles. OPN correlated negatively and significantly with muscle lathosterol in men (r = -0.58, P = 0.001, n = 29) but not in women (r = -0.21, P = 0.48, n = 14). Correspondingly, it also correlated negatively and significantly with the muscle lathosterol to muscle cholesterol ratio (r = -0.60, P = 0.001) in men but not in women (r = -0.13, P = 0.65). Plasma levels of OPN had a non-significant inverse correlation with plasma lathosterol and the plasma lathosterol to plasma cholesterol ratio. Plasma OPN concentrations were not related to plant sterols, cholesterol and 27-hydroxycholesterol.
Conclusions: Tissue markers of cholesterol synthesis were related to plasma OPN, particularly in men. This suggests that there is interplay between OPN and cholesterol metabolism in human cells.
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| http://dx.doi.org/10.2143/AC.62.2.2020239 | DOI Listing |
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Article Synopsis
- The study investigates the relationship between plasma osteopontin (OPN) levels and cholesterol metabolites in individuals with normal to mildly elevated cholesterol levels.
- OPN levels showed a significant negative correlation with muscle lathosterol and its ratio to cholesterol, especially in men, while this correlation was not found in women.
- The findings suggest a potential link between OPN and cholesterol metabolism, indicating that OPN may play a role in atherosclerosis development.
Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels.
J Lipid Res
December 2005
Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Consumption of plant sterols and treatment with ezetimibe both reduce cholesterol absorption in the intestine. However, the mechanism of action differs between the two treatments, and the consequences of combination treatment are unknown. Therefore, we performed a double-blind, placebo-controlled, crossover study for the plant sterol component with open-label ezetimibe treatment.
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