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Prolonged tamoxifen treatment induces iron deposition and ferroptosis in the liver.
FASEB J
January 2025
Department of Nutrition, Second Military Medical University, Shanghai, China.
Tamoxifen is an inhibitor of estrogen receptors and was originally developed for breast cancer therapy. Besides, tamoxifen is widely used for Cre-estrogen receptor-mediated conditional knockout in transgenic mice. However, we found that the 3-month feeding of 0.
View Article and Find Full Text PDFPro-inflammatory diet affects markers of iron metabolism in healthy older adults.
J Trace Elem Med Biol
December 2024
Department of Nutrition and Gerontology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany; Department of Geriatrics and Medical Gerontology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany; TraceAge-DFG Research Unit on Interactions of Essential Trace Elements in Healthy and Diseased Elderly, Potsdam-Berlin-Jena-Wuppertal, Germany.
Article Synopsis
- Older adults often face inflammation and poor nutrition, which can impact their iron levels.
- The study evaluated the diets of healthy older individuals, measuring their iron markers and inflammation indicators compared to younger adults.
- Results indicated that a pro-inflammatory diet in older adults leads to higher levels of inflammation and disrupted iron management, particularly influencing ferritin and hepcidin concentrations.
Hepcidin inhibits hepatocyte apoptosis through the PERK pathway in acute liver injury and fibrosis.
Hepatol Commun
January 2025
Liver Research Center, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health and National Clinical Research Center of Digestive Diseases, Beijing, China.
Article Synopsis
- Hepcidin, a hormone crucial for iron regulation, is shown to play a role in liver fibrosis by preventing hepatocyte apoptosis via the PERK pathway.
- A study using CCl4-induced liver fibrosis in hepcidin knockout mice revealed that the absence of hepcidin led to more severe liver damage and increased apoptosis compared to wild-type mice.
- Transcriptomic analysis identified that the PERK molecule is upregulated in the absence of hepcidin, suggesting its involvement in regulating cell death in liver injury, highlighting hepcidin's potential as a therapeutic target for liver fibrosis.
Novel loci and biomedical consequences of iron homoeostasis variation.
Commun Biol
December 2024
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Iron homoeostasis is tightly regulated, with hepcidin and soluble transferrin receptor (sTfR) playing significant roles. However, the genetic determinants of these traits and the biomedical consequences of iron homoeostasis variation are unclear. In a meta-analysis of 12 cohorts involving 91,675 participants, we found 43 genomic loci associated with either hepcidin or sTfR concentration, of which 15 previously unreported.
View Article and Find Full Text PDFPharmacokinetics and Pharmacodynamics of Rusfertide, a Hepcidin Mimetic, Following Subcutaneous Administration of a Lyophilized Powder Formulation in Healthy Volunteers.
Drugs R D
December 2024
Protagonist Therapeutics, Inc., 7575 Gateway Blvd, Suite 110, Newark, CA, 94560-1160, USA.
Background And Objective: Hepcidin, an endogenous peptide hormone, binds to ferroportin and is the master regulator of iron trafficking. Rusfertide, a synthetic peptide, is a potent hepcidin mimetic. Clinical studies suggest rusfertide may be effective in the treatment of polycythemia vera.
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