AI Article Synopsis
- The study examines the challenges related to postoperative infections in abdominal cluster transplantation, specifically focusing on two cases.
- A combination of five immunosuppressive drugs was used, leading to severe infections from Gram-negative bacteria and Candida species, along with complications from Cytomegalovirus (CMV).
- The findings suggest that improving immunosuppressive strategies and enhancing early infection diagnosis and treatment are crucial for better managing post-transplant complications.
Article Abstract
Objective: To investigate the characteristic and management of postoperative infection in abdominal cluster transplantation.
Methods: Preliminary experience of two cases of abdominal cluster transplantation including small intestine was reviewed.
Results: Combination of five immunosuppressive agents based on tacrolimus was used. Severe Gram-negative bacillus infections occurred. The majority of invasive fungal infections was due to Candida species. Cytomegalovirus (CMV) infection increased monocytes and caused eosinopenia and an inversion of the CD4(+) to CD8(+) cell ratio in recipient I, and human CMV matrix proteins pp71 (CMV-pp71) was detected and identified in bile by PCR. Microabscesses in liver transplant biopsies were presented.
Conclusions: Infectious complications after cluster transplantation were complicated. Strategies to optimize the immunity suppression protocol and early diagnosis and treatment will be important to reduce infection after abdominal cluster transplantation.
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