Deuterium (2H) double-quantum filtered (DQF) NMR spectroscopy of nucleus pulposus (NP) tissues from human intervertebral discs is reported. The DQF spectral intensities, DQ build-up rates, and DQF-detected rotating-frame spin-lattice relaxation times are sensitive to the degree of hydration of the NP tissue, and display a monotonous correlation with age between 15 and 80 years. The implications of this work are that the changes in water dynamics as detected via DQF NMR spectroscopy may be used as a probe of tissue degeneration in NP, particularly in the early stages of degeneration to which most standard NMR methods are not sensitive.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mrm.21231 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sulfur-containing spiroketals from and evaluations of their anti-inflammatory effect.
Beilstein J Org Chem
October 2023
Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya, Aichi 464-8650, Japan.
spp. are a key source of sulfur-containing spiroketal glycosides with potential anti-inflammatory activity. In this study, three new sulfur-containing spiroketals - breynin J (), epibreynin J (), and probreynogenin () - along with four known compounds - probreynin I (), phyllaemblic acid (), breynin B (), and epibreynin B () - were isolated from the roots of .
View Article and Find Full Text PDFStructural analysis of a water insoluble polysaccharide from pearl millet and evaluating its prebiotic activity.
Int J Biol Macromol
December 2023
Department of Biotechnology, Indian Institute of Technology Kharagpur, West Midnapore, West Bengal 721302, India. Electronic address:
Epidemiological studies have shown an inverse correlation between dietary intake of prebiotics and the risk of chronic diseases. Pearl millet is a potential economic source to develop a new class of prebiotics in the form of its polysaccharide. In the present study, the chemical structure of a water insoluble homopolysaccharide (PMG), and its prebiotic properties were investigated.
View Article and Find Full Text PDFActinoflavosides B-D, Flavonoid Type Glycosides from Tidal Mudflat-Derived Actinomyces.
Mar Drugs
September 2022
Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Korea.
Three new secondary metabolites, actinoflavosides B-D (-), were discovered in the culture broth of two actinomycete strains (JML48 and JMS33) that were isolated from tidal mudflat sediment in Muan, Republic of Korea. The planar structures of the actinoflavosides were elucidated by MS, UV, and NMR analyses. The stereochemistry of an aminosugar, 2,3,6-trideoxy-3-amino-ribopyranoside in the actinoflavosides was determined by -based configuration analysis using values obtained from DQF-COSY experiments and modified Mosher's method.
View Article and Find Full Text PDFChanges in Natural Silk Fibres by Hydration, Tensile Loading and Heating as Studied by H NMR: Anisotropy in NMR Relaxation Times.
Polymers (Basel)
September 2022
School of Chemistry, University of East Anglia, Norwich NR4 7TJ, UK.
silkworm natural silk is a fibrous biopolymer with a block copolymer design containing both hydrophobic and hydrophilic regions. Using H NMR relaxation, this work studied natural silk fibres oriented at 0° and 90° to the static magnetic field to clarify how measured NMR parameters reflect the structure and anisotropic properties of hydrated silk fibres. The FTIR method was applied to monitor the changes in the silk I and -sheet conformations.
View Article and Find Full Text PDFHeterogenicity within the LPS Structure in Relation to the Chosen Genomic and Physiological Features of the Plant Pathogen .
Int J Mol Sci
February 2022
Faculty of Chemistry, University of Gdansk, 63 Wita Stwosza, 80-308 Gdansk, Poland.
is a pectinolytic plant pathogenic bacterium causing high economic losses of cultivated plants. The highly devastating potential of this phytopathogen results from the efficient production of plant cell wall-degrading enzymes, i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!