AI Article Synopsis
- The study aimed to assess the effectiveness of gastrointestinal (GI) tonometry in measuring end-organ perfusion during burn shock and subsequent resuscitation in swine.
- Male swine experienced a severe burn and underwent resuscitation, with various measures of gastrointestinal function monitored every six hours to evaluate changes due to shock and recovery.
- Results indicated that ileal tonometry provided more reliable data than gastric tonometry, showing better recovery metrics in response to resuscitation after thermal injury.
Article Abstract
Introduction: The occurrence of organ failure following thermal injury, despite restoration of hemodynamic parameters and urine output during resuscitation, has led to efforts to measure end-organ perfusion. The purpose of this 24-h study was to evaluate the utility of gastrointestinal (GI) tonometry during burn shock and resuscitation.
Methods: Male swine (n=11, 23.3+/-0.9 kg) were anesthetized with ketamine and propofol. A 70% full thickness burn was caused by immersion in 97 degrees C water for 30 s. Resuscitation with lactated Ringer's, 4 ml/kg/% burn, was begun at hour 6 and titrated to urine output (UO). Arterial blood gases and pulmonary artery catheter data were measured every 6 h. Gastric and ileal regional PCO(2) (PrCO(2)) were measured continuously by air tonometry, and the gastric and ileal intramucosal pH (pHi) and PCO(2) gap (PrCO(2)-PaCO(2)) were calculated every 6 h.
Results: Gastric pHi, ileal PrCO(2), ileal pHi, and ileal PCO(2) gap (but not gastric PrCO(2) or PCO(2) gap) all decreased with shock and were restored to baseline levels by resuscitation. Changes in ileal PrCO(2) were of greater magnitude and demonstrated decreased variability than those in gastric PrCO(2).
Conclusions: In this model, ileal tonometry outperformed gastric tonometry during burn shock and resuscitation.
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| http://dx.doi.org/10.1016/j.burns.2006.11.013 | DOI Listing |
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