A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@pubfacts.com&api_key=b8daa3ad693db53b1410957c26c9a51b4908&a=1): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 176

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 176
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 250
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3122
Function: getPubMedXML

File: /var/www/html/application/controllers/Detail.php
Line: 575
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 489
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Ripply2 is essential for precise somite formation during mouse early development. | LitMetric

AI Article Synopsis

  • Ripply1 and Ripply2 are thought to be transcriptional corepressors that are expressed in overlapping regions during somitogenesis in mice and zebrafish.
  • Ripply1 is known to be essential for somite segmentation in zebrafish, but the role of Ripply2 was unclear until the study involved creating Ripply2 knock-out mice.
  • The knock-out mice showed defects in axial skeleton segmentation, disrupted somite segmentation, and altered expression of Notch2 and Uncx4.1, indicating that Ripply2 plays a key role in somite segmentation and the development of rostrocaudal polarity.

Article Abstract

The regions of expression of Ripply1 and Ripply2, presumptive transcriptional corepressors, overlap at the presomitic mesoderm during somitogenesis in mouse and zebrafish. Ripply1 is required for somite segmentation in zebrafish, but the developmental role of Ripply2 remains unclear in both species. Here, we generated Ripply2 knock-out mice to investigate the role of Ripply2. Defects in segmentation of the axial skeleton were observed in the homozygous mutant mice. Moreover, somite segmentation and expression of Notch2 and Uncx4.1 were disrupted. These findings indicate that Ripply2 is involved in somite segmentation and establishment of rostrocaudal polarity.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.febslet.2007.05.017DOI Listing

Publication Analysis

Top Keywords

somite segmentation
12
role ripply2
8
ripply2
6
ripply2 essential
4
essential precise
4
somite
4
precise somite
4
somite formation
4
formation mouse
4
mouse early
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!