High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.
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| http://dx.doi.org/10.1016/j.bmcl.2007.05.019 | DOI Listing |
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