Administration of a single dose of lead nitrate (200 mg/kg) to pregnant rats (Day 18 of gestation) resulted in the appearance of destructive brain changes in their offspring on postnatal Day 40, including the cysts, foci of glial cell proliferation, pyknosis of neurons, decrease of NADH- and NADPH-diaphorase activity in neocortical and hippocampal neurons. The reduction of both neuronal density in the cortex and cortical thickness was also demonstrated. The intensity of free radical oxidation in the cortex was increased 3-fold, while the concentration of lipid hydroperoxides was increased 3.9 times, and the resistance to peroxidation was decreased by a factor of 3, which is indicative of oxidative stress. Possible mechanisms of the pathological changes development are discussed.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Dementia Care Practice.
Alzheimers Dement
December 2024
VA Boston Healthcare System, Jamaica Plain, MA, USA.
Background: The built environment is increasingly recognized as a valid medical intervention, known to affect mental and social health, which can carry consequences for cognitive function. "Transitional spaces" are indoor/outdoor areas designed to foster connections to the surrounding world and boost well-being including windows, porches, and public parks. Little is known about the space design characteristics that might help improve social and mental health.
View Article and Find Full Text PDFRevealing the process and mechanism of non-grain production of cropland in rapidly urbanized deqing County of China.
J Environ Manage
January 2025
Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:
Non-grain production of cropland (NGPCL) is a common consequence of rapid urbanization, but excessive NGPCL threatens food security and sustainable cropland use. However, the evolutionary processes and mechanisms of different NGPCL types remain largely unknown, compromising the scientific basis for NGPCL management. Thus, taking rapidly urbanized Deqing as the study area, this research constructed an NGPCL theoretical framework from the perspective of agricultural location, classified NGPCL types using Landsat images, random forest algorithm and Google Earth Engine, and revealed their spatiotemporal changes and different influencing factors through the Multinomial Logit Regression model, and provided targeted zoning and categorized policy suggestions.
View Article and Find Full Text PDFEfficacy of home based computerized adaptive cognitive training in patients with post stroke cognitive impairment: a randomized controlled trial.
Sci Rep
January 2025
Department of Psychology, Government MLB Girls PG College, Kila Bhawan, Indore, Madhya Pradesh, India.
Post-stroke cognitive impairment is a common consequence of stroke, characterized by deficits in language, cognitive functioning, functional abilities. Innovative technological approaches, such as computerized cognitive retraining, offer promising strategies for mitigating the cognitive challenges. Despite their potential, the impact of these interventions on neuropsychological function and daily living capabilities has poor outcomes.
View Article and Find Full Text PDFHistorically, in-person contact between patients and nurses in home-based care has been pivotal in palliative care and hospice care. The provision of home-based palliative care services could be challenged by the projected increase in patients who need palliative care and by the expected shortage of nurses. Digital health services could constitute one measure for delivering high-quality palliative care, enabling patients to stay home.
View Article and Find Full Text PDFThree in four children age 12-23 months missed opportunities for vaccination in Sub-Saharan African countries: a multilevel mixed effect analysis of demographic health and surveys 2016-2023.
BMC Public Health
January 2025
Department of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Background: Despite vaccination being the most cost-effective means to prevent disease and its adverse consequences, missing opportunities for vaccination remains a critical public health challenge. Many SSA countries still couldn't reach the target endorsed by the Global Vaccine Action Plan. Identifying contributing factors helps policymakers and planners to design potential interventions to avert missing opportunities for vaccination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!