Purpose: To use the global flash multifocal electroretinogram (mfERG) in patients with asymmetric glaucoma to determine whether retinal function is affected in fellow eyes that have no glaucomatous visual field defects.
Methods: Forty normal subjects and 12 patients with asymmetric glaucoma were recruited for visual field and mfERG measurement. The mfERG was assessed by using a global-flash stimulation paradigm with four video frames: 103 scaled hexagonal elements followed by a dark frame, a global-flash frame, and a dark frame. The localized luminance difference was set at 96%, 65%, 49%, and 29% display contrast during the four different test conditions, respectively. The first-order kernel response was measured, and the "adaptive index" which has been used previously was calculated.
Results: In fellow eyes with normal visual fields, the amplitude of the induced component (IC) was significantly reduced, and the adaptive index was reduced by a factor of almost 10 (P < 0.0001), as it was in the glaucomatous eyes. Although the adaptive index in the better (fellow) eye of the patients with glaucoma was slightly higher than in the eyes with diagnosed glaucoma, these differences were not statistically significant.
Conclusions: The significant reduction of the adaptive index in the better eyes in subjects with asymmetric glaucoma shows that the fast adaptive mechanism(s) were reduced in these eyes. This implies that eyes that have functionally normal visual acuity and visual fields have abnormal fast-adaptive mechanisms.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1167/iovs.06-0962 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cup-to-disc ratio measured clinically and via OCT in pediatric patients being monitored as glaucoma suspects for suspicious optic discs.
Front Ophthalmol (Lausanne)
December 2024
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Purpose: Compare cup-to-disc ratio (CDR) measured by clinical assessment and optical coherence tomography (OCT) in pediatric eyes being monitored as glaucoma suspects for suspicious optic disc appearance.
Design: Retrospective cross-sectional study.
Methods: An institutional study following 221 eyes from 122 unique pediatric glaucoma suspects being monitored due to increased or asymmetric appearance of CDR.
Use of a Novel Virtual Reality-Based Pupillography Device for Glaucoma Management: Cross-Sectional Cohort Pilot Study.
Klin Monbl Augenheilkd
December 2024
Analytics, machineMD, Bern, Switzerland.
Article Synopsis
- Standard methods for monitoring glaucoma, like OCT and SAP, have limitations, prompting a study to assess if RAPD and PLR testing could provide more objective measures.
- In a pilot study with 21 patients, RAPD was calculated through PLR measurements, showing a significant correlation with differences in retinal nerve fiber layer thickness.
- The findings suggest that combining RAPD and SAP can better predict optic nerve damage, potentially allowing for longitudinal monitoring of glaucoma using PLR alone in the future.
Asymmetric Glaucoma and Corresponding Hearing Impairment.
J Clin Med
October 2024
Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
: This study aims to explore the potential relationship between unilateral or asymmetric glaucoma and ipsilateral hearing impairment. : In this retrospective study, visual and hearing functions were assessed in patients with unilateral or asymmetric glaucoma. Correlations between retinal nerve fiber layer (RNFL) thickness, visual field mean deviation (MD) values, and pure tone audiometry (PTA) measurements across various frequencies were analyzed to explore potential associations between visual and ipsilateral hearing functions.
View Article and Find Full Text PDFThe association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression.
Graefes Arch Clin Exp Ophthalmol
October 2024
Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea.
Article Synopsis
- The study aimed to evaluate how eye movements impact the progression of primary open-angle glaucoma by analyzing biomechanical changes in the optic nerve head (ONH).
- Researchers created a virtual ONH model for 118 glaucoma patients, looking at factors like axial length and optic disc radius, and simulated how these changed under different eye movements.
- Results showed that patients with progression of glaucoma experienced greater stress and asymmetric stress distribution in the ONH during eye rotation, particularly linked to optic disc size and cup deepening.
Ocular manifestations for misdiagnosing acute angle closure secondary to lens subluxation.
Front Med (Lausanne)
October 2024
Zibo Central Hospital, Zibo, Shandong, China.
Introduction: The objective of this study was to assess the clinical characteristics and biometric parameters, as measured by the IOLMaster, of patients suffering from acute secondary angle closure due to zonular dialysis (ASAC-ZD) who were misdiagnosed with acute primary angle closure (APAC).
Methods: In this retrospective study, 34 ASAC-ZD and 39 APAC eyes were examined. Sex, age, best-corrected visual acuity, axial length (AL), anterior chamber depth (ACD), anterior chamber depth standard deviation (ACDSD), lens thickness (LT), and lens thickness standard deviation (LTSD) were measured using the IOLMaster and compared between the two groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!