Neutral and cationic tripyridylporphyrin-D-galactose conjugates were synthesized and their antiviral activity against herpes simplex virus type 1 (HSV-1) was evaluated. At non-cytotoxic concentrations the studied compounds show significant antiviral activity after photoactivation. The influence of photoactivation on drug treated cells was also analyzed, at different times of infection with HSV-1, for a neutral (1b) and a cationic glycoporphyrin (3b) derivative. The results show that the inhibition of the viral yield is more dependent on photoactivation for compound 1b than for compound 3b. These two compounds also differ in the inhibitory effect during the viral replicative cycle: while compound 3b inhibits the viral yield at all the addition times assayed, compound 1b is more efficient in later times of infection.
This study focused on the development of cholesterol-free fusogenic liposomes with different surface charge with the aim of improving biofilm penetration. In vitro assessments of the liposomes included physical stability, biocompatibility, fusion with microbial cells, and the ability to penetrate established biofilms. Using dynamic light scattering, cholesterol-free, fusogenic liposomes were found to be < 200 nm in size with small size distribution (PDI < 0.
Rare earth elements (REEs) are critical materials to modern technologies. They are obtained by selective separation from mining feedstocks consisting of mixtures of their trivalent cation. We are developing an all-aqueous, bioinspired, interfacial separation using peptides as amphiphilic molecular extractants.
The electronic structures of lanthanide monoxides (LnO/LnO) and monosulfides (LnS/LnS) for all lanthanide series elements (Ln = La-Lu) have been systematically analyzed with sophisticated quantum chemical calculations. The ground electronic configuration has been determined to be Ln 4f6s or 4f for the neutral molecules and Ln 4f for the cations. The low-lying energy states resulting from spin-orbit coupling and ligand field effects have been resolved using spin-orbit multiconfiguration quasi-degenerate second-order perturbation theory calculations.
Omura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
The avermectins make up a biologically relevant class of complex natural products that continue to inspire the development of new strategies in chemical synthesis. Herein, we disclose a concise synthesis of the southern core of avermectin aglycon. The key hydrobenzofuran was forged by either reductive cyclization or cycloisomerization, both using a cationic palladium precatalyst.
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Flexible Zn-air batteries (FZABs) hold significant promise in diverse application scenarios with high safety and compatibility yet are still impeded by byproduct formation and poor water retention. Here, the neutral hydrogel electrolyte GAHE is engineered by polymerizing acrylamide (AM) in a solution composed of cationic guar gum (CGG) and acetate salts to conquer the above challenges. The acetate anions (OAc) exert a pH near 7 to effectively inhibit the side reactions triggered by H.
