The routine use of chaperones during medical examinations, including intimate examinations, is variable. Practice varies between countries and also within them. Use of a chaperone may protect patients from sexual abuse by medical or nursing practitioners. An appropriate chaperone may also protect healthcare practitioners from false accusations. This article considers issues surrounding the use of chaperones and suggests a chaperoning policy for sexual health clinics, while acknowledging that it may not be appropriate or acceptable to all patients or medical staff, or for different parts of the world.
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http://dx.doi.org/10.1071/sh07022 | DOI Listing |
Nat Cell Biol
January 2025
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Outer mitochondrial membrane (OMM) proteins communicate with the cytosol and other organelles, including the endoplasmic reticulum. This communication is important in thermogenic adipocytes to increase the energy expenditure that controls body temperature and weight. However, the regulatory mechanisms of OMM protein insertion are poorly understood.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Bionano Technology, Gachon University, Seongnam, Korea, Republic of (South).
Background: Clusterin, a multifunctional glycoprotein, is implicated in Alzheimer's disease (AD) pathogenesis due to its roles in Aβ aggregation and clearance. Hence, understanding the specific interactions between Clusterin and Aβ would be a crucial for unraveling AD mechanisms and exploring therapeutic avenues. Previous study reported that clusterin bound with Aβ directly.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Delaware State University, Dover, DE, USA.
Background: Aggregation of transactive response DNA binding protein 43 (TDP-43) is the major pathological feature of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recently, in up to 50% of Alzheimer's disease (AD) cases TDP-43 pathology was discovered and this pathology has been referred to as limbic-predominant age-related TDP43 encephalopathy (LATE). Several studies reported that TDP-43 binds to heat shock protein family B (small) member 1 (HSPB1 or HSP27) but no functional evaluation of this interaction has been explored.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Centre for Studies on Prevention of Alzheimer's disease (StoP-AD Centre), Douglas Mental Health Institute, Montreal, QC, Canada.
Background: Clusterin is a major cholesterol transporter in the central nervous system (CNS) and different SNPs in the CLU gene have been associated with Alzheimer's disease (AD) risk. The rs11136000_T variant in the CLU gene has been shown to decrease the risk of AD. In this work, we investigate the role of the CLU rs11136000_T protective variant and of the clusterin protein throughout different phases of the AD spectrum.
View Article and Find Full Text PDFRev Int Androl
December 2024
Department of Sports Science, College of Education, Zhejiang University, 310058 Hangzhou, Zhejiang, China.
Background: Testicular torsion-detorsion damage is a common ischemia-reperfusion injury brought on by an excess of reactive oxygen species. Reactive oxygen species may affect cellular differentiation by regulating gene expression. The gene expression in the testis is essential for spermatogenesis.
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