Jo-1 syndrome is an autoimmune disease with autoantibodies against the histidyl tRNA synthetase. Characteristic clinical findings include inflammatory myopathy and interstitial lung disease. We present the first case of a patient with Jo-1 syndrome (positive Jo-1 autoantibodies, myositis, interstitial alveolitis) who developed Hodgkin's lymphoma of nodular-sclerosing type. Thus, patients with Jo-1 syndrome and immunosuppressive therapy similar to other patients with autoimmune disease are at risk to develop lymphomas and should therefore be monitored carefully.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00428-007-0429-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hidden in Plain Sight: Antisynthetase Syndrome Masquerading As Acute Coronary Syndrome and Heart Failure.
Cureus
November 2024
Respiratory Medicine, Dartford and Gravesham National Health Service (NHS) Trust, Dartford, GBR.
Article Synopsis
- * High-resolution CT scans showed ground-glass opacities and indicated a potential overlap of nonspecific interstitial pneumonia and organizing pneumonia, while ruling out pulmonary embolism.
- * Treatment with pulse-dose methylprednisolone and tacrolimus resulted in significant clinical improvement, emphasizing the need for prompt diagnosis and team-based management in conditions like antisynthetase syndrome.
Quantification of autoantibodies using a luminescent profiling method in autoimmune interstitial lung disease.
Front Immunol
November 2024
Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, United States.
Autoantibodies are important for the diagnosis of autoimmune interstitial lung disease (ILD). Standard immunoassays have limitations, including their qualitative nature and/or a narrow dynamic range of detection, hindering the usefulness of autoantibodies as biomarkers of disease activity. Here, the luciferase immunoprecipitation system (LIPS) was evaluated for measuring myositis-specific and other lung-related autoantibodies in 25 subjects with idiopathic inflammatory myopathies (IIM), 26 with Sjögren's disease (SjD), and 10 healthy volunteers.
View Article and Find Full Text PDFArticle Synopsis
- - The study focused on anti-synthetase syndrome (ASSD), a rare autoimmune disease, aiming to identify clinical and lab features for potential classification criteria.
- - Researchers analyzed data from 948 ASSD patients and 1077 control subjects, finding that certain symptoms like arthritis and specific autoantibodies were more common in ASSD cases.
- - The findings will assist clinicians in diagnosing ASSD and contribute to creating more standardized, data-driven classification criteria for the syndrome.
Myositis-specific and myositis-associated autoantibodies: their clinical characteristics and potential pathogenic roles.
Immunol Med
October 2024
Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Article Synopsis
- Recent identification of specific autoantibodies in various idiopathic inflammatory myopathies (like dermatomyositis and anti-synthetase syndrome) highlights their importance in diagnosis and treatment.
- These autoantibodies vary in terms of which organs they affect, severity of disease, and how patients respond to treatments, which is key for developing effective therapies.
- The review discusses findings such as the role of anti-TIF1γ antibodies in mice models, changes in gene expression in muscle tissues from patients with anti-Mi2 antibodies, and the activation of T cells by the Jo-1 antigen, contributing to the understanding of myositis pathogenesis.
An Observational Study on the Clinical Characteristics and Prognosis of Patients With Interstitial Lung Disease Secondary to Dermatomyositis and Antisynthetase Syndrome.
Int J Rheumatol
September 2024
Department of Rheumatology and Immunology The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province 530021, China.
Article Synopsis
- - The study analyzed clinical characteristics and prognostic factors of patients with idiopathic inflammatory myopathy (IIM) who also had interstitial lung disease (ILD) and included 39 males and 111 females with a mean onset age of 50.4 years and a median disease duration of 3 months.
- - Among the patients, 97 had dermatomyositis (DM-ILD) and 53 had antisynthetase syndrome (ASS-ILD), with DM-ILD patients showing higher rates of anti-MDA5 antibodies and common symptoms such as skin ulcers and rapidly progressing ILD, while ASS-ILD patients showed higher rates of anti-Jo-1 antibodies and pericardial effusion.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!