Objective: The aim of this investigation was to use 3D (threedimensional) analysis of maxillary casts to document and graphically demonstrate the clinically-visible vertical deviation of the premaxilla and lateral segments from a defined reference plane, and to describe the effect of presurgical dentofacial orthopedic treatment and cleft lip operation.
Material And Methods: The maxillary morphology of 17 infants with bilateral cleft lip and palate (investigation group) was examined by means of 3D cast measurement with a reflex microscope from the time of birth to the age of 11 months. All the patients were treated at the Dental Center of the University of Leipzig according to the same treatment approach [15], which in the first year of life entails the insertion of a modified palatal plate according to Hotz [17, 18], one-stage surgical repair of the cleft lip (at the age of 4-6 months on average), and closure of the hard and soft palates 6 months later. We selected the casts of 14 patients to use as the control group; they had been treated according to a different approach at, what at that time was, the Wolfgang Rosenthal Clinic for Plastic and Reconstructive Maxillofacial Surgery in Thallwitz.
Results: We observed vertical deviations of the cleft segments during the investigation period. Following surgical repair of the cleft lip, there was a caudal shift of the premaxilla in both groups that was cranially rotated before the operation. The investigation group also revealed a reduction in the vertical deviation of the lateral segments. We noted a harmonization in the position of the segments in the investigation group, however, this harmonization was not achieved in the control group.
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http://dx.doi.org/10.1007/s00056-007-0648-7 | DOI Listing |
Cell Death Discov
January 2025
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. Our previous studies demonstrated that mutations associated with AEC syndrome lead to p63 protein misfolding and aggregation, exerting a dominant-negative effect.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Oral and Maxillofacial Surgery, University Hospital of Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria.
: Defects in maxillary and mandibular continuity are common in maxillofacial practice. They can occur after trauma, osteonecrosis, congenital jaw deformities, or surgical resection of benign or malignant tumours. Reconstruction with microvascular bone flaps and subsequent prosthetic rehabilitation is considered the contemporary first line treatment.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
December 2024
Department of Medical Genetics and Genomic Medicine, University of Campinas (UNICAMP), SP, Brazil. Electronic address:
This study describes the results of whole exome sequencing in the etiological investigation and genetic counseling of families presenting with non-syndromic oral clefts with vertical transmission recorded in the Brazilian Database on Craniofacial Anomalies. Whole exome sequencing was performed in 18 families presenting with non-syndromic oral clefts with vertical transmission, and variant filtering was used to identify rare, and also possibly pathogenic variants in genes associated with oral clefts. Overall, our study identified seven families (38.
View Article and Find Full Text PDFCongenit Anom (Kyoto)
January 2025
Division of Research and Treatment for Oral and Maxillofacial Congenital Anomalies, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.
Pregnancy loss is a significant concern worldwide, encompassing miscarriage and stillbirth. Miscarriage, defined as the loss of a baby before 28 weeks of gestation, accounts for approximately 15% of pregnancies. Stillbirth, occurring at or after 28 weeks of gestation, affects nearly 2.
View Article and Find Full Text PDFBehav Sci (Basel)
January 2025
Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.
As individuals with a cleft lip and palate (CLP) transition into adulthood, they face unique employment challenges related to income, job stability, and fewer career options. This study explored these challenges through two focus group discussions with 19 participants (aged 21-38), primarily women, to understand their employment experiences. Thematic analysis revealed the following three main themes: (1) physical factors, (2) psychosocial factors, and (3) overcoming employment challenges, with nine sub-themes including speech, hearing, appearance, health, childhood experiences, societal expectations, lack of self-confidence, communication improvement, and self-esteem building.
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