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The Subtle evolution of pulmonary parenchymal changes: A case of lady windermere syndrome emerging from chronic MAC infection in an immunocompetent patient with scoliosis.
Radiol Case Rep
January 2025
Mayo hospital, Anarkali, Lahore, 54000, Punjab, Pakistan.
Mycobacterium avium complex, a commonly seen infection in individuals with a compromised immune system, can also affect people who are immunocompetent. One particularly important manifestation is in elderly females with a competent immune system, involving the middle lobe and lingula lobe of the lung. This is known as Lady Windermere syndrome (LWS).
View Article and Find Full Text PDFLady Windermere syndrome (LWS) is a disease caused by a non-tuberculous (NTM) that is commonly found in thin women who voluntarily suppress their cough reflex. The NTM that causes this syndrome is complex, an organism commonly present in chlorinated city water and soil. Patients with LWS are tall, lean, elderly white women.
View Article and Find Full Text PDFLady Windermere Syndrome: A Rare Differential Diagnosis for Hemoptysis.
Cureus
April 2024
Internal Medicine, Sri Jayewardenepura General Hospital, Colombo, LKA.
Mycobacterium avium complex (MAC) is often observed in immunocompromised individuals. However, when pulmonary MAC infection occurs in immunocompetent individuals, particularly elderly females, characteristically involving the middle lobe and lingula lobe of the lung, it is known as Lady Windermere syndrome (LWS). A 64-year-old female patient with no significant comorbidities presented with a history of low-grade intermittent fever and dry cough for one-month duration complicated with hemoptysis for two days.
View Article and Find Full Text PDFNontuberculous Mycobacteria, Mucociliary Clearance, and Bronchiectasis.
Microorganisms
March 2024
Unidad de Investigación, Complejo Asistencial Universitario de León, Gerencia Regional de Salud de Castilla y León (SACYL), Altos de Nava, s/n, 24071 León, Spain.
Nontuberculous mycobacteria (NTM) are environmental and ubiquitous, but only a few species are associated with disease, often presented as nodular/bronchiectatic or cavitary pulmonary forms. Bronchiectasis, airways dilatations characterized by chronic productive cough, is the main presentation of NTM pulmonary disease. The current Cole's vicious circle model for bronchiectasis proposes that it progresses from a damaging insult, such as pneumonia, that affects the respiratory epithelium and compromises mucociliary clearance mechanisms, allowing microorganisms to colonize the airways.
View Article and Find Full Text PDFLady Windermere Syndrome: Unravelling an Older Lady's Nightmare.
Cureus
October 2023
Internal Medicine, Saint Vincent Hospital, Worcester, USA.
Infection with nontuberculous mycobacteria (NTM) is an increasingly important cause of pulmonary disease, particularly in immunocompromised patients or those suffering from chronic lung conditions. However, though rare, non-tubercular mycobacterial infection and bronchiectasis may also occur in an immunocompetent patient. This unusual condition is typically seen in middle-aged or elderly white females, with bronchiectasis having a predilection for the middle lobe and lingula.
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