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Primary intraosseous squamous cell carcinoma with pagetoid spread arising in periapical odontogenic epithelium of the maxilla.
Med Mol Morphol
January 2025
Faculty of Medicine, Department of Oral and Maxillofacial Surgery, Fukuoka University, Fukuoka, Japan.
To date, pagetoid spread-the proliferation of pagetoid cells in intraepidermal lesions, as observed in secondary extramammary Paget's disease-has not been reported in squamous epithelium derived from the extension of head and neck carcinomas. Herein, we report a case of pagetoid squamous cell proliferation associated with a primary intraosseous carcinoma (PIOC) arising in the periapical lesion of the maxilla, a finding not reported previously. A 60-year-old man presented with prostate adenocarcinoma and bilateral pubic bone, ilium bone, and sacral bone metastases.
View Article and Find Full Text PDFPrimary intraosseous squamous cell carcinoma originating from a mandibular odontogenic cyst: A case report.
Sci Prog
December 2024
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Qingdao University, Shandong Province, China.
Malignant transformation arising in the background of jaw cysts is a rare and often misdiagnosed condition, particularly when developing from residual root-derived cysts. We present a case of epithelial malignancy originating from a residual root-derived cyst in the mandible of a man around 50 years old. Histological evaluation of the sections revealed that the epithelial lining of the cystic lesion contained well-differentiated squamous cell carcinoma components.
View Article and Find Full Text PDFImaging findings in a case of primary intraosseous carcinoma arising from a mandibular cyst.
Oral Radiol
November 2024
, Fukuoka, Japan.
Primary intraosseous carcinoma not otherwise specified (PIOC NOS) is a rare tumor assumed to arise from the epithelium, such as odontogenic cysts or benign tumors. Its clinical and imaging diagnoses are often challenging, especially in the early stages, as it mimics jaw cysts and benign tumors, and no specific findings have been identified. This report presents the case of a 66-year-old male patient with mandibular PIOC, highlighting the imaging findings over time.
View Article and Find Full Text PDFExpression of ALKBH5 in Odontogenic Lesions.
Appl Immunohistochem Mol Morphol
January 2025
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, Srinakharinwirot University, Wattana, Bangkok, Thailand.
N6-methyladenosine (m6A) is the most abundant epigenetic RNA modification in eukaryotes and plays a role in various cancers in humans. This m6A modification is regulated by m6A writers, erasers, and readers. One of the m6A erasers is α-ketoglutarate-dependent dioxygenase homolog 5 (ALKBH5).
View Article and Find Full Text PDFA generalizable procedure for Brown's class Ⅱ and Ⅲ defects reconstruction with deep circumflex iliac artery flap using computer-assisted technique.
J Craniomaxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 430079, Wuhan, China; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 430079, Wuhan, China. Electronic address:
Article Synopsis
- The study focuses on the use of deep circumflex iliac artery (DCIA) flaps for reconstructing maxillary defects, aiming to improve surgical efficiency and outcomes through computer-assisted techniques.
- Researchers reviewed 10 cases of maxillary reconstruction, noting various types of defects and documenting donor site choices, types of flaps used, and the success of surgical procedures.
- Results indicated 9 successful recoveries with no complications, while one case required additional surgery due to necrosis, demonstrating the potential reliability of the DCIA flap method when combined with advanced technology.
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