Cleft and craniofacial healthcare is complex, warranting a specialized, multidisciplinary approach. The modern cleft team is best suited to deliver appropriate care to both affected individuals and their families.
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Comprehensive three-dimensional microCT and signaling analysis reveal the teratogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on craniofacial bone development in mice.
Ecotoxicol Environ Saf
January 2025
Department of Stomatology, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, No. 242, Guangji Road, Suzhou, Jiangsu Province 215000, China. Electronic address:
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in utero can result in osteogenic defect during palatogenesis, but the effects on other craniofacial bones and underlying mechanisms remain to be characterized. By treating pregnant mice with TCDD (40 μg/kg) at the vital craniofacial patterning stages (embryonic day 8.5, 10.
View Article and Find Full Text PDFCranial Base Changes After Trans-sutural Distraction Osteogenesis in Growing Patients With Cleft Lip/Palate and Midface Hypoplasia.
J Craniofac Surg
November 2024
Department of Plastic Surgery, Peking University Third Hospital, Beijing, China.
Background: Transesutural distraction osteogenesis (TSDO) is a method of correcting midfacial hypoplasia (MH) secondary to cleft lip and palate (CLP) without osteotomy. However, there has been little research on how the morphology of the cranial base changes postoperatively or whether any correction of the cranial base occurs.
Materials And Methods: This retrospective study included 35 pediatric patients with MH secondary to CLP, who underwent TSDO treatment.
Normative CLEFT-Q Data From the General Dutch Population.
J Craniofac Surg
November 2024
Department of Plastic and Reconstructive Surgery and Hand Surgery, Erasmus Medical Center, Rotterdam.
Patient-Reported Outcome Measures (PROMs), such as the CLEFT-Q, have become essential for outcomes in patients with CL/P. Normative values of the CLEFT-Q for non-CL/P peers have not yet been established. This study aims to establish normative values for the CLEFT-Q in the general Dutch population.
View Article and Find Full Text PDFCleft-Related Revision Procedures: Surgeon Perspectives on Shared Decision-Making and a Decision Aid Prototype.
Cleft Palate Craniofac J
January 2025
Section of Plastic Surgery, Michigan Medicine, Ann Arbor, MI, USA.
Objective: Decision-making for elective cleft lip and nose revisions varies widely, from patient-led decisions to more paternalistic approaches. As these procedures incur additional scarring that may impact future interventions, patients should be equipped to participate in these surgical decisions. We thus developed a decision aid based on international standards, and to ensure methodologic rigor, we sought feedback from other surgeons regarding shared decision-making and potential barriers to adopting the decision aid.
View Article and Find Full Text PDFExparel and Outpatient Alveolar Bone Grafting: A Feasibility Study.
Cleft Palate Craniofac J
January 2025
Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, USA.
Objectives: To examine the feasibility of outpatient alveolar bone grafting (ABG) using Exparel (bupivacaine liposome injectable suspension) for donor site analgesia.
Design: Retrospective, observational study.
Setting: Single institution, 39-month retrospective review.
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