We report a method for making ultra-thin PDMS membrane devices. Freely suspended membranes as thin as 70 nm have been fabricated. Bulging tests were performed with a custom built fluidic cell to characterize large circular membranes. The fluidic cell allows the media (such as air or water) to wet one side of the membrane while maintaining the other side dry. Pressure was applied to the membrane via a liquid manometer through the fluidic cell. The resulting load-deflection curves show membranes that are extremely flexible, and they can be reproducibly loaded and unloaded. Such devices may potentially be used as mechanical and chemical sensors, and as a bio-nano/micro interface to study cellular mechanics in both static and dynamic environments.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10544-007-9070-6 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A novel vascularized urethra-on-a-chip model.
Sci Rep
March 2025
Department of Urology, University Medical Center Utrecht, Utrecht, The Netherlands.
The male urethra transports urine and semen. Any disease of the male urethra, hindering normal voiding or ejaculation, has a major impact on quality of life. Urethral stricture disease is common and molecular research into urethral strictures is hampered by the lack of reliable models of the human urethra.
View Article and Find Full Text PDFA gut-brain axis on-a-chip platform for drug testing challenged with donepezil.
Lab Chip
March 2025
Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Current drug development pipelines are time-consuming and prone to a significant percentage of failure, partially due to the limited availability of advanced human preclinical models able to better replicate the complexity of our body. To contribute to an advancement in this field, we developed an multi-organ-on-a-chip system, that we named PEGASO platform, which enables the dynamic culturing of human cell-based models relevant for drug testing. The PEGASO platform is composed of five independent connected units, which are based on a previously developed millifluidic organ-on-a-chip device (MINERVA 2.
View Article and Find Full Text PDFA Versatile and Modular Microfluidic System for Dynamic Cell Culture and Cellular Interactions.
Micromachines (Basel)
February 2025
College of Science & General Studies, Alfaisal University, Riyadh 11533, Saudi Arabia.
A versatile and modular microfluidic system for cell co-culture has been developed. Microfluidic chips, each featuring dual compartments separated by a porous membrane, have been fabricated and assembled within the system to facilitate fluidic interconnection and cell-cell communication through the chip assembly. A set of fluidic valves has been successfully integrated to regulate the flow through the chip assembly.
View Article and Find Full Text PDFProduction of Uniform Droplets and Lipid Nanoparticles Using Perfluoropolyether-Based Microfluidic Devices.
Micromachines (Basel)
January 2025
Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro Wonmi-gu, Bucheon-si 14662, Gyeonggi-do, Republic of Korea.
Microfluidic devices are greatly affected by the materials used. The materials used in previous studies had problems in various aspects, such as processing, adsorption, and price. This study will investigate the materials needed to overcome such problems.
View Article and Find Full Text PDFPrussian-Blue Catalysis and NFC Synergy: a Battery-Free Laser-Induced Graphene-Based Platform for Urine Glucose Monitoring at Point-of-Care.
Adv Sci (Weinh)
March 2025
Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, Barcelona, 08193, Spain.
Prussian-blue nanoparticles (PBNPs) show promise in electrochemical hydrogen peroxide (HO) sensing but face operational stability challenges without complex strategies. This study introduces a simplified, polymer-based synthesis method, enhancing their stability in a single step. Chemical polymerization of Prussian-blue (PB) and poly(3,4-ethylenedioxythiophene) (PEDOT) with gelatin as a polycationic soft template yields a self-assembled PB-infused Catalytic Hetero-interface Architecture (PB-CHIA) that remarkably improves the stability of PBNPs and offers functional groups for enzyme immobilization, supporting robust biosensing applications.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!