Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2214/AJR.06.1616 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Risk-Adapted Starting Ages of Colorectal Cancer Screening for People With Diabetes or Metabolic Syndrome.
Aliment Pharmacol Ther
December 2024
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Background: Individuals with diabetes and metabolic syndrome have an increased risk of colorectal cancer (CRC), suggesting earlier screening than the average-risk population may be warranted.
Aims: To derive risk-adapted starting ages of CRC screening for people with diabetes or metabolic syndrome.
Methods: We determined 5-year cumulative risks of CRC at individual ages between 30 and 50 across Europe (overall and individually for Germany, France, the UK and Italy) and North America (the United States and Canada) based on the GLOBOCAN 2022 database.
An update on laboratory detection and interpretation of antiphospholipid antibodies for diagnosis of antiphospholipid syndrome: guidance from the ISTH-SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies.
J Thromb Haemost
November 2024
Department of Haematology, Cancer Institute, University College London, London, United Kingdom; Department of Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom.
Antiphospholipid syndrome (APS) diagnosis is dependent on the accurate detection and interpretation of antiphospholipid antibodies (aPL). Lupus anticoagulant (LA), anticardiolipin antibodies (aCL), and anti-beta2 glycoprotein I antibodies (aβ2GPI) remain the cornerstone of the laboratory part of APS diagnosis. In the 2023 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) APS classification criteria, the type of laboratory parameters remain essentially unchanged compared with the updated Sapporo classification criteria, and aCL and aβ2GPI measurement are still restricted to enzyme-linked immunosorbent assays (ELISAs) with moderate and high titer aPL thresholds defined as 40 and 80 Units, respectively, and a cutoff calculated by the 99th percentile has been abandoned.
View Article and Find Full Text PDFComputationally guided high-throughput engineering of an anti-CRISPR protein for precise genome editing in human cells.
Cell Rep Methods
October 2024
Acrobat Genomics, Inc., San Carlos, CA 94070, USA. Electronic address:
The application of CRISPR-Cas systems to genome editing has revolutionized experimental biology and is an emerging gene and cell therapy modality. CRISPR-Cas systems target off-target regions within the human genome, which is a challenge that must be addressed. Phages have evolved anti-CRISPR proteins (Acrs) to evade CRISPR-Cas-based immunity.
View Article and Find Full Text PDFContinuous epidural analgesia and interscalene brachial plexus block as postoperative analgesia for Pancoast tumor resection: a case report.
AME Case Rep
August 2024
Department of Anesthesiology and Pain Medicine, Juntendo University Hospital, Tokyo, Japan.
Article Synopsis
- Pancoast tumor resection surgery can lead to intense postoperative pain, particularly due to potential damage to the brachial plexus, causing shoulder and upper extremity pain.
- A continuous brachial plexus block and continuous epidural analgesia were used to manage this pain in a 58-year-old patient undergoing left upper lobectomy and chest wall resection.
- Post-surgery, the patient's pain was effectively controlled, maintaining low levels of pain (2-3 for shoulder and 0-1 for wound pain) using a combination of ropivacaine and fentanyl for the analgesia methods.
Enhancing chatbot performance for imaging recommendations: Leveraging GPT-4 and context-awareness for trustworthy clinical guidance.
Eur J Radiol
December 2024
Department of Diagnostic and Interventional Radiology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Purpose: To investigate if GPT-4 improves the accuracy, consistency, and trustworthiness of a context-aware chatbot to provide personalized imaging recommendations from American College of Radiology (ACR) appropriateness criteria documents using semantic similarity processing: In addition, we sought to enable auditability of the output by revealing the information source the decision relies on.
Material And Methods: We refined an existing chatbot that incorporated specialized knowledge of the ACR guidelines by upgrading GPT-3.5-Turbo to its successor GPT-4 by OpenAI, using the latest version of LlamaIndex, and improving the prompting strategy.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!