Synthesis of alkylamides of dipeptides as potential plasmin inhibitors.

Acta Pol Pharm

Department of Organic Chemistry, Medical University of Białystok, 1 Kilińskiego Str., 15-089 Białystok, Poland.

Published: August 2007

Four dipeptide alkylamides with general formula H-D-Phe-L-Lys-NH-X, where X = cyclohexyl, - (CH2)5NH2, -(CH2)2-OH and hexyl were obtained. Effect of these compounds on amidolytic and fibrinolytic activity of plasmin was examined.

Download full-text PDF

Source

Publication Analysis

Top Keywords

synthesis alkylamides
4
alkylamides dipeptides
4
dipeptides potential
4
potential plasmin
4
plasmin inhibitors
4
inhibitors dipeptide
4
dipeptide alkylamides
4
alkylamides general
4
general formula
4
formula h-d-phe-l-lys-nh-x
4

Similar Publications

We present, for the first time, an efficient ligand-free iron-copper catalyzed cross-coupling reaction involving a variety of aryl, heteroaryl halides (including chlorides, bromides, and iodides), and alkyl bromides with diverse aryl and aliphatic primary amides, conducted under solvent-minimized conditions. This economically competitive protocol successfully yielded the corresponding cross-coupling products, N-arylamides and N-alkylamides, in good to excellent yields with broad substrate scope (65 examples) and tolerance to several sensitive functionalities (including heterocycles). No conventional work-up is required for this protocol, and the developed method is applicable for gram-scale synthesis.

View Article and Find Full Text PDF

has been traditionally used to strengthen the immune system. Therefore, herein, we investigated the potential of aqueous extracts (AEs) obtained from flowers (F), leaves (L), or roots (R) as an immune booster in human primary monocyte-derived macrophages (hMDMs). Additionally, to identify the main class of compounds (phenolic/carboxylic acids vs.

View Article and Find Full Text PDF

Coumarins rather than alkylamides evoke the numbing orosensation of pomelo peel.

Food Chem

January 2025

Citrus Research Institute, Southwest University, Chongqing, 400712, China; National Citrus Engineering Research Center, Chongqing, 400712, China. Electronic address:

Article Synopsis
  • Liangpingyou pomelo has a unique numbing aftertaste that researchers sought to understand, ruling out Sichuan pepper compounds as the cause.
  • Through testing pomelo peel juice, three coumarins—meranzin hydrate, isomeranzin, and marmin—were identified as responsible for the numbing sensation.
  • Sensory analysis confirmed specific concentration thresholds for numbness and other tastes, and molecular docking indicated that these coumarins interact with certain taste receptors (TRPV1, TPRA1, KCNK3).
View Article and Find Full Text PDF

Although recent evidence indicated significant phenol and alkylamide interaction in aqueous solutions, the gastrointestinal digestion influence of the combination remains unclear. This study aims to investigate phenol and alkylamide interaction during in vitro digestion, focusing on bioaccessibility and bioactivity, including α-glucosidase inhibition and cellular antioxidant activity. Additionally, the structural mechanism of phenol and alkylamide interaction during in vitro digestion was explored.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!