The objective of this study was to investigate whether skeletal mandibular asymmetry associated with unilateral and anterior crossbite will lead to lip asymmetry. The subjects were 26 females, 13 controls and 13 true skeletal asymmetric age-matched patients (24-50 years). The study group was diagnosed as asymmetric according to visual and panoramic radiographic examination and exhibited a unilateral anterior crossbite, an asymmetric mandible, and a deviation of the chin. The control group was visually symmetric and exhibited all forms of tooth malalignment without the presence of a crossbite. Digitized images of the frontal facial photographs of all the subjects, taken in an intercuspal contact position, were analysed for upper and lower lip symmetry pre- and post-orthodontic treatment. The upper and lower lips were subdivided into two quadrants each and the surface area of each quadrant was measured and expressed as a percentage of the total surface area of the relevant lip. The degree of lip asymmetry was obtained by calculating the difference in percentage area between the two quadrants of each lip. In the study group, the lower lip quadrant on the crossbite side was increased pre-treatment (56.85 +/- 1.75 per cent), while the contralateral side was reduced (43.15 +/- 1.75 per cent, P < 0.005), resulting in 13.7 per cent asymmetry. After treatment, the respective lip areas were 52.12 +/- 0.64 and 47.88 +/- 0.64 (P < 0.01) and asymmetry was significantly reduced (4.25 +/- 1.29 per cent). In the control group, the differences between the lower lip quadrant areas (range 48.5-51.5 per cent) were small (less than 3 per cent asymmetry) and did not change post-treatment. The findings demonstrate that in this study group, lower lip symmetry was mainly controlled by the support provided through the dental interarch relationships and less by skeletal factors.
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http://dx.doi.org/10.1093/ejo/cjm022 | DOI Listing |
Cell Death Discov
January 2025
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, 02129, USA.
Ankyloblepharon-Ectodermal Defects-Cleft Lip/Palate (AEC) syndrome is a rare genetic disorder caused by mutations in the TP63 gene, which encodes a transcription factor essential for epidermal gene expression. A key feature of AEC syndrome is chronic skin erosion, for which no effective treatment currently exists. Our previous studies demonstrated that mutations associated with AEC syndrome lead to p63 protein misfolding and aggregation, exerting a dominant-negative effect.
View Article and Find Full Text PDFInt J Oral Maxillofac Surg
January 2025
Department of Oral and Maxillofacial Surgery, Tsukuba Gakuen Hospital, Tsukuba, Ibaraki, Japan.
Dermatofibrosarcoma protuberans (DFSP) is a low-grade, malignant, spindle cell tumour with an infiltrative growth pattern and a high local recurrence rate. Cases of oral DFSP are rare. This report describes a case of DFSP occurring in the labial mucosa.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
Faculty of Dental Medicine, University of Medicine and Pharmacy "Iuliu Hatieganu", 8, Victor Babes Str., 400347 Cluj-Napoca, Romania.
: Surgical treatment of extensive tumors of the lower lip generates important defects in its structure and functions. Over time, a multitude of reconstruction options for these defects have been imagined. Unfortunately, the majority involve the use of both local and regional flaps, which either lack labial structure or disorganize the oral commissures as nodal oral function points.
View Article and Find Full Text PDFAntibiotics (Basel)
December 2024
Nanomedicine Department, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia.
The emergence of multidrug-resistant bacteria presents a significant global health threat. Liposomal antibiotics have shown a potential to improve antibiotic delivery and efficacy. This study aimed to develop liposomes encapsulating tobramycin (TOB) and methylglyoxal (MGO) to enhance TOB activity while reducing bacterial adhesion and biofilm formation.
View Article and Find Full Text PDFBeijing Da Xue Xue Bao Yi Xue Ban
February 2025
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing 100081, China.
Objective: To establish a similarity measurement model for patients with dentofacial deformity based on 3D craniofacial features and to validate the similarity results with quantifying subjective expert scoring.
Methods: In the study, 52 cases of patients with skeletal Class Ⅲ malocclusions who underwent bimaxillary surgery and preoperative orthodontic treatment at Peking University School and Hospital of Stomatology from January 2020 to December 2022, including 26 males and 26 females, were selected and divided into 2 groups by sex. One patient in each group was randomly selected as a reference sample, and the others were set as test samples.
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