The focus of the 6th workshop is on lysine, arginine, and related amino acids. Functions, metabolic pathways, clinical uses, and upper tolerance intakes are emphasized in the articles that follow. Lysine is arguably the most deficient amino acid in the food supply of countries where poverty exists, and since the discovery of the nitric oxide synthase pathway, arginine has come into prominence clinically because of the role of nitric oxide in cardiovascular physiology and pathophysiology.
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http://dx.doi.org/10.1093/jn/137.6.1599S | DOI Listing |
Food Chem
January 2025
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
This study aimed to investigate the inhibitory pathways of basic amino acids (Histidine, Lysine, and Arginine) on the formation of PhIP in the glucose/creatinine/phenylalanine model system. The inhibitory effects were found to depend on both the chemical structure and concentration of the basic amino acids, with Lysine showing the strongest inhibitory effect. Due to the lower reaction barrier of basic amino acids, their potential inhibitory mechanism is proposed to involve competition with phenylalanine for glucose.
View Article and Find Full Text PDFJ Chem Inf Model
January 2025
Department of Chemistry, Faculty of Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Tau is a microtubule (MT)-associated protein that binds to and stabilizes the MTs of neurons. Due to its intrinsically disordered nature, it undergoes several post-translational modifications (PTMs) that are intricately linked to both the physiological and pathophysiological roles of Tau. Prior research has shown phosphorylation and O-GlcNAcylation to have contrasting effects on Tau aggregation; however, the precise molecular mechanisms and potential synergistic effects of these modifications remain elusive.
View Article and Find Full Text PDFACS Phys Chem Au
January 2025
Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José dos Campos, 12247-014 São Paulo, Brazil.
The unique properties and versatile applications of natural deep eutectic solvents (NaDES) have sparked significant interest in the field of green chemistry. Comprised of natural components that form liquids at room temperature through strong noncovalent electrostatic interaction, these solvents are cost-effective, nontoxic, and versatile. Betaine chloride-based NaDES, in particular, have shown promise in biocatalysis and sugar extraction due to their excellent properties.
View Article and Find Full Text PDFProtein Sci
February 2025
Department of Chemistry and Biochemistry, Center for RNA Biology, The Ohio State University, Columbus, Ohio, USA.
Loz1 is a zinc-responsive transcription factor in fission yeast that maintains cellular zinc homeostasis by repressing the expression of genes required for zinc uptake in high zinc conditions. Previous deletion analysis of Loz1 found a region containing two tandem CH zinc-fingers and an upstream "accessory domain" rich in histidine, lysine, and arginine residues to be sufficient for zinc-dependent DNA binding and gene repression. Here we report unexpected biophysical properties of this pair of seemingly classical CH zinc fingers.
View Article and Find Full Text PDFPathogens
January 2025
Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
The papillomavirus E2 protein regulates the transcription, replication, and segregation of viral episomes within the host cell. A multitude of post-translational modifications have been identified which control E2 functions. A highly conserved di-lysine motif within the transactivation domain (TAD) has been shown to regulate the normal functions of the E2 proteins of BPV-1, SfPV1, HPV-16, and HPV-31.
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