Authors' experience in detecting neoplasms by a computerized telethermographic system in animal models is reported. The new technique seems to have a great potential as a photo-diagnostic method particularly when followed by the surgical treatment or the photodynamic therapy (PDT) of the neoplastic lesions. Literature reports on the PDT of tumors are reviewed.
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J Colloid Interface Sci
January 2025
Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Qingdao 266237 PR China. Electronic address:
Despite phthalocyanine has excellent photodynamic and photothermal effects as a photosensitizer and photothermal agent, hydrophobicity and aggregation limits its biological application. In this paper, phthalocyanine-cyanine co-assembled nanoparticles were designed to modulate the dimensions and morphology by introducing water-soluble cyanine. The cyanine had the ability to transform the nanomaterials from microrods to nanospheres, thus successfully constructing photoactivated nanomedicines.
View Article and Find Full Text PDFBiomed Mater
January 2025
Physics and Applied Mathematics, Pakistan Institute of Engineering and applied Sciences, P.O. Box Nilore, Islamabad., Islamabad, Islamabad, 44000, PAKISTAN.
Ficus Carica extract (FC) is a natural herb that has received a lot of interest in cancer treatment due to its potential anticancer activities against various malignancies. However, due to FC's low bioavailability and low solubility, its clinical use as an anti-cancer medicine is constrained. The current study aimed to prepare FC-loaded PLGA nanoparticles (NPs) for cancer treatment.
View Article and Find Full Text PDFFuture Med Chem
January 2025
Department of Biophysics, School of Basic Medical Sciences, Health Science Centre, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R., China.
The rise of antibiotic-resistant Gram-positive bacterial infections poses a significant threat to public health, necessitating the exploration of alternative therapeutic strategies. A photosensitizer (PS) can convert energy from absorbed photon into reactive oxygen species (ROS) for damaging bacteria. This photoinactivation action bypassing conventional antibiotic mechanism is less prone to resistance development, making antibacterial photodynamic therapy (aPDT) highly efficient in combating Gram-positive bacteria.
View Article and Find Full Text PDFDalton Trans
January 2025
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, Guangdong Basic Research Center of Excellence for Functional Molecular Engineering, School of Chemistry, Sun Yat-sen University, Guangzhou, 510275, P. R. China.
Photodynamic therapy (PDT), as a non-invasive cancer treatment, offers significant advantages including high temporal-spatial selectivity, minimal surgical intervention, and low toxicity, thereby garnering considerable research interest from across the world. In this study, we have developed a series of dinuclear cyclometalated Ir(III) complexes as potential two-photon photodynamic anticancer agents. These Ir(III) complexes demonstrate significant two-photon absorption (2PA) cross-sections ( = 66-166 GM) and specifically target mitochondria.
View Article and Find Full Text PDFMikrobiyol Bul
January 2025
Uşak Üniversitesi Tıp Fakültesi, Biyofizik Anabilim Dalı, Uşak.
Layşmanyaz, yaklaşık 90'dan fazla ülke ve bölgeden bildirilen, ciddi ve endemik bir bulaşıcı hastalıktır. Kutanöz layşmanyaz (KL) ise vücudun açıkta kalan bölgelerinde oluşan, başlıca semptomları arasında vektör Phlebotomus ısırığından altı ay sonra kronikleşebilen veya kendiliğinden iyileşebilen ciltte tek, birden fazla ülserli veya nodüler lezyonlar bulunan, ölümcül olmayan ancak kalıcı izler bırakabilen bir hastalıktır. Klasik tedavi yöntemleri, uygulamada zorluk, direnç gelişimi ve yan etki gibi bir dizi soruna neden olmaktadır.
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