Background: Thermoregulation is critical for survival in space, especially during contingencies demanding of human cognitive and physical performance. A review of the negative feedback human thermoregulatory system is provided. The Advanced Crew Escape Suit is worn by astronauts during ascent and descent on the Space Shuttle to provide active cooling for nominal and contingency operations and protection from loss of cabin pressure mishaps. Failure of a thermal system control element during a recent Shuttle flight resulted in a single point failure that could have elevated cabin temperature, possibly resulting in cognitive deficits of the pilot during the reentry and landing phases.
Methods: The efficacy of the existing cooling equipment and procedures for maintaining crew thermal comfort in the event of such a failure was assessed. The Wissler and 41-node thermoregulatory models were used to conduct a parametric study of Shuttle cabin temperatures and resulting thermal effects on crew.
Results: Under high metabolic loads, crewmember core temperatures and heat storage are shown to increase beyond allowable limits using this analysis. Resulting levels of thermal stress may exceed standardized limits, after which cognitive performance and manual tracking ability are diminished.
Discussion: The operational procedure for entry and landing during this failure scenario may result in significant thermal compromise to crewmembers, including cognitive and manual performance deficits. Revision of the flight rule governing crew actions during compromise of cabin thermal control has been undertaken to minimize thermal stress on returning Shuttle crewmembers. Modifications to the crew thermal protection system for the Shuttle are suggested.
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Phys Med Biol
January 2025
Department of Physics, Aristotle University of Thessaloniki, University Campus, Thessaloniki, 54124, GREECE.
Magnetic nanoparticle hyperthermia (MNH) emerges as a promising therapeutic strategy for cancer treatment, leveraging alternating magnetic fields (AMFs) to induce localized heating through magnetic nanoparticles (MNPs). However, the interaction of AMFs with biological tissues leads to non-specific heating caused by eddy currents, triggering thermoregulatory responses and complex thermal gradients throughout the body of the patient. While previous studies have implemented the Atkinson-Brezovich limit to mitigate potential harm, recent research underscores discrepancies between this threshold and clinical outcomes, necessitating a re-evaluation of this safety limit.
View Article and Find Full Text PDFJ Therm Biol
January 2025
School of Agriculture and Food Sustainability, Animal Science Group, The University of Queensland, Gatton, QLD, Australia, 4343. Electronic address:
The creation of any model is complex requiring vast amounts of data, typically gathered over a series of experiments. Specifically the temperature humidity index (THI) and heat load index (HLI) are used as management tools to implement mitigation strategies during hot climatic conditions. Exposure of the testes to hot climatic conditions has a negative impact on spermatogenesis in the bull, and other species.
View Article and Find Full Text PDFJ Therm Biol
December 2024
NTU Psychology, Nottingham Trent University, Nottingham, NG1 4FQ, United Kingdom; Brain Function Research Group, School of Physiology, Faculty of Health Science, University of the Witwatersrand, South Africa.
As opportunistic generalists occupying a range of ecological niches, chacma baboons (Papio ursinus) are considered a highly flexible species of relatively low conservation priority. Underlying their ecological flexibility is a repertoire of behavioral strategies observed in response to ecological stressors. Although these strategies are relatively well-documented, we know very little about how they impact upon an individual's thermal and energetic physiology, which can influence population-level reproductive potential in the face of climatic warming.
View Article and Find Full Text PDFJ Therm Biol
December 2024
School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, 85287, USA; Julie Ann Wrigley Global Futures Laboratory, Arizona State University, Tempe, AZ, 85287, USA. Electronic address:
As global temperatures rise due to climate change, the frequency and intensity of heatwaves are increasing, posing significant threats to human health, productivity, and well-being. Thermoregulation models are important tools for quantifying the risk of extreme heat, providing insights into physiological strain indicators such as core and skin temperatures, sweat rates, and thermal comfort levels. This study evaluated four thermoregulation models of varying complexity, differentiated by the geometry and underlying thermoregulatory mechanisms.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Neuroscience and Cell Biology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan.
This study investigated the impact of multiple nerve block methods (local anesthesia, conventional radiofrequency thermocoagulation [CRF], and pulsed radiofrequency [PRF]) on thermoregulation. Focusing on hypothalamic function, the effects of local anesthesia, CRF, and PRF on central and peripheral temperatures were analyzed and compared. Our findings revealed that all three nerve block groups cause a decrease in central temperature, with the CRF group exhibiting the most pronounced effect.
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