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Needle-Free Targeted Injections Using Bubble Laser Technology in Therapeutics.
Langmuir
November 2024
UKM─Department of Electrical, Electronic and Systems Engineering, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia UKM, Bangi 43600, Malaysia.
This work explores bubble laser technology as an alternative to needles in injection systems for vaccination, cancer treatment, insulin delivery, and catheter hygiene. The technology leverages laser-induced microfiltration and bubble dynamics to create high-speed pneumatic jets that penetrate the skin without needles, addressing discomfort, infection risk, and needle-related concerns. The system's performance is analyzed based on laser wavelength, pulse duration, and Gaussian beam droplet size.
View Article and Find Full Text PDFEvaluation of gunshot injuries to long bones from pneumatic weapons using a human thigh model. Part II. Presentation and discussion of the detailed results of tests of gunshots of the anterior surface of the femur with 5.5 mm and 6.35 mm caliber shot.
Arch Med Sadowej Kryminol
October 2024
Faculty of Medical Sciences, Academy of Silesia, Poland.
Introduction: The development of pneumatic shooting has led to the construction of technologically advanced devices with discharge energies similar to those of firearms. The pneumatic weapons ammunition market offers a variety of shot which varies in penetration properties and the extent of gunshot damage. In view of the ease of "tuning" of air rifles, a study was conducted of the inlet damage to the anterior femoral surface after pneumatic gunshots.
View Article and Find Full Text PDFMicroorganism microneedle micro-engine depth drug delivery.
Nat Commun
October 2024
Department of Materials Science and Engineering, Stanford University, Stanford, CA, USA.
Article Synopsis
- * Researchers developed a pneumatic microneedle patch that uses live Enterobacter aerogenes as microengines, which generate gas to actively control drug delivery by pushing drugs deeper into the skin.
- * The system demonstrates over 200% increased drug delivery depth and effectively delivers calcitriol in a psoriasis animal model, showcasing significant potential for enhanced drug efficiency and on-demand control.
Big-bubble DALK: A technique in evolution.
Ocul Surf
October 2024
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Ophthalmology Unit, Dipartimento di Scienze Mediche e Chirurgiche, Alma Mater StudiorumUniversity of Bologna, Bologna, Italy. Electronic address:
Article Synopsis
- - Deep anterior lamellar keratoplasty (DALK) is a surgical technique for treating corneal disorders without affecting the endothelium, which helps prevent rejection and late graft failure compared to traditional penetrating keratoplasty (PK).
- - The introduction of the big-bubble technique (BBT) improved the efficiency and consistency of DALK by using air to separate corneal layers, resulting in high-quality grafts comparable to PK.
- - Understanding the anatomy behind BB formation, including the significance of Dua's layer, is essential for successful DALK procedures; ongoing improvements in BBT are increasing its use in corneal transplants with healthy endothelium.
Surgical Strategies to Manage Stromal Interface Irregularity Following Deep Anterior Lamellar Keratoplasty.
Cornea
December 2024
Department of Ophthalmology, University Magna Graecia of Catanzaro, Catanzaro, Italy.
Purpose: The purpose of this study was to describe the various surgical approaches to manage stromal interface irregularity following deep anterior lamellar keratoplasty (DALK).
Methods: This interventional case series included patients requiring repeat keratoplasty procedures for stromal interface opacity and/or irregularity following DALK. The following surgical techniques with the aim of restoring transparency and regularity of the central optical zone and improving visual acuity in eyes that underwent unsuccessful DALK were performed: 1) simple anterior lamellar graft exchange, 2) repeat DALK with pneumatic dissection, 3) repeat DALK with deepening of manual lamellar dissection, 4) small diameter stripping of the central stroma-endothelium-Descemet complex and its replacement with a new endothelial lamella, and 5) 2-piece microkeratome-assisted mushroom penetrating keratoplasty.
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