Mechanical allodynia, defined as a reduction in mechanical pain threshold, is an essential diagnostic feature of inflammation of the periodontal ligament. Traditional methods for measuring mechanical allodynia in a tooth are not quantitative. This study evaluated the reliability of a new bite force transducer to measure mechanical pain thresholds, which might have application as a quantitative diagnostic aid for measuring mechanical allodynia in patients with apical periodontitis. To determine inter-observer reliability, subjects (n = 40) were given standardized instructions before generating maximal bite force on maxillary first molars; readings were then recorded by three examiners for a total of ten readings per examiner. To determine the test-retest reliability, the initial examiner then retested at two different sessions. The intraclass correlation coefficient was fair to substantial for inter-observer reliability (0.3-0.64) and substantial for intra-observer reliability (0.63-0.68). Thus, the force transducer used in our study is a reliable method to measure mechanical pain thresholds in endodontic patients.
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http://dx.doi.org/10.1016/j.joen.2006.06.003 | DOI Listing |
Cell Mol Neurobiol
January 2025
Department of Neurology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, 430030, China.
Neuropathic pain, a prevalent complication following spinal cord injury (SCI), severely impairs the life quality of patients. No ideal treatment exists due to incomplete knowledge on underlying neural processes. To explore the SCI-induced effect on nociceptive circuits, the protein expression of c-Fos was analyzed as an indicator of neuronal activation in a rat contusion model exhibiting below-level pain.
View Article and Find Full Text PDFMinerva Anestesiol
January 2025
Department of Anesthesiology and Reanimation, Karadeniz Technical University, Trabzon, Türkiye -
Biochem Pharmacol
January 2025
Division of Pharmacology, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Japan.
The pathogenesis of painful diabetic neuropathy (PDN) is complicated and remains not fully understood. A disintegrin and metalloprotease 17 (ADAM17) is an enzyme that is responsible for the degradation of membrane proteins. ADAM17 is known to be activated under diabetes, but its involvement in PDN is ill defined.
View Article and Find Full Text PDFPain
January 2025
Department of Neuroscience, Center for Advanced Pain Studies, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX.
Hyperalgesic priming is a model system that has been widely used to understand plasticity in painful stimulus-detecting sensory neurons, called nociceptors. A key feature of this model system is that following priming, stimuli that do not normally cause hyperalgesia now readily provoke this state. We hypothesized that hyperalgesic priming occurs because of reorganization of translation of mRNA in nociceptors.
View Article and Find Full Text PDFBrain Behav Immun
January 2025
Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas MD Anderson Cancer Center, Houston, USA. Electronic address:
Preclinical and clinical studies have established that autoreactive immunoglobulin G (IgG) can drive neuropathic pain. We recently demonstrated that sciatic nerve chronic constriction injury (CCI) in male and female mice results in the production of pronociceptive IgG, which accumulates around the lumbar region, including within the dorsal root ganglia (DRG) and spinal cord, facilitating the development of neuropathic pain. These data raise the intriguing possibility that neuropathic pain may be alleviated by reducing the accumulation of IgG.
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