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Establishment of an Ex Vivo Human Corneal Endothelium Wound Model.
Transl Vis Sci Technol
January 2025
UCL Institute of Ophthalmology, University College London, London, UK.
Purpose: A human model able to simulate the manifestation of corneal endothelium decompensation could be advantageous for wound healing and future cell therapy assessment. The study aimed to establish an ex vivo human cornea endothelium wound model where endothelium function can be evaluated by measuring corneal thickness changes.
Methods: The human cornea was maintained in an artificial anterior chamber, with a continuous culture medium infusion system designed to sustain corneal endothelium and epithelium simultaneously.
Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves' Ophthalmopathy.
Invest Ophthalmol Vis Sci
January 2025
Department of Ophthalmology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Purpose: Graves' ophthalmopathy (GO), the most common extrathyroidal manifestation of Graves' disease, is disabling and disfiguring. Recent studies have shown that statins have a protective effect on individuals with GO. Statins were reported to trigger ferroptosis in some disorders, but little is known about whether statins protect against GO via ferroptosis.
View Article and Find Full Text PDFRecurrent nodular episcleritis as a manifestation of long COVID.
BMJ Case Rep
January 2025
University Hospitals Coventry and Warwickshire NHS Trust, Coventry, Coventry, UK
A woman in her 50s presented with redness, eye pain, watering and photophobia of the left eye starting 1 week after she tested positive for COVID-19. She was diagnosed with left eye episcleritis and started on topical steroids. As the steroids were being gradually tapered, she developed a recurrence.
View Article and Find Full Text PDFExploring the impact of nano platinum-hydrogen saline on oxygen-induced retinopathy in neonatal rats.
J Matern Fetal Neonatal Med
December 2025
Department of Pediatrics, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan No.1 Hospital, Wuhan, China.
Objective: The objective of this study is to assess the impact of nano platinum-hydrogen saline (Pt NPs + H) on oxygen-induced retinopathy (OIR) in neonatal rats, with the goal to contribute new insights into the therapeutic strategies for retinopathy of prematurity.
Methods: Pt NPs + H formulation was synthesized to address OIR in a rat model. Subsequent examination included the assessment of retinal blood vessel distribution and morphology through hematoxylin and eosin (HE) and isolectin B4 (IB4) staining techniques.
Femtosecond Laser Arcuate Keratotomy vs Toric Intraocular Lens Implantation in Cataract Surgery: A Randomized Clinical Trial.
JAMA Ophthalmol
January 2025
Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China.
Importance: After cataract surgery, postoperative residual astigmatism can influence a patient's visual quality and satisfaction. Finding ways to minimize this astigmatism is important.
Objective: To compare the clinical outcomes of femtosecond laser arcuate keratotomy (FSAK) and toric intraocular lens (TIOL) implantation for astigmatism correction in patients undergoing femtosecond laser-assisted cataract surgery.
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