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radiosensitivity and Mn antioxidant content: antigenic preservation and pathobiology.
mBio
December 2024
School of Medicine, Department of Pathology, Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland, USA.
The bacterium responsible for Lyme disease, , accumulates high levels of manganese without iron and possesses a polyploid genome, characteristics suggesting potential extreme resistance to radiation. Contrary to expectations, we report that wild-type B31 cells are radiosensitive, with a gamma-radiation survival limit for 10 wild-type cells of <1 kGy. Thus, we explored radiosensitivity through electron paramagnetic resonance (EPR) spectroscopy by quantitating the fraction of Mn present as antioxidant Mn metabolite complexes (H-Mn).
View Article and Find Full Text PDFA Reliable Multifaceted Solution against Foodborne Viral Infections: The Case of RiLK1 Decapeptide.
Molecules
May 2024
National Reference Laboratory for Foodborne Viruses, Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 00161 Rome, Italy.
Food-borne transmission is a recognized route for many viruses associated with gastrointestinal, hepatic, or neurological diseases. Therefore, it is essential to identify new bioactive compounds with broad-spectrum antiviral activity to exploit innovative solutions against these hazards. Recently, antimicrobial peptides (AMPs) have been recognized as promising antiviral agents.
View Article and Find Full Text PDFMyosin heavy chain-derived peptide of promotes proliferation and differentiation in osteoblasts and bone formation and maintains bone homeostasis in ovariectomized mice.
Food Funct
June 2023
School of Food Science and Technology, Collaborative Innovation Center of Seafood Deep Processing, National Engineering Research Center of Seafood, Dalian Polytechnic, University, Dalian 116034, China.
is an important commercial fish rich in nutrients required for daily metabolism. However, the regulation of peptides (GMP) on osteoblast growth remains unclear. In order to clarify the regulatory effects of GMP on osteoblasts, the effects of GMP on the growth of MC3T3-E1 cells were investigated, and the osteogenic peptides were identified and screened.
View Article and Find Full Text PDFMechanistic insights into the mitigation of Aβ aggregation and protofibril destabilization by a D-enantiomeric decapeptide rk10.
Phys Chem Chem Phys
September 2022
School of Chemistry & Biochemistry, Thapar Institute of Engineering & Technology, Patiala-147004, Punjab, India.
According to clinical studies, the development of Alzheimer's disease (AD) is linked to the abnormal aggregation of amyloid-β (Aβ) peptides into toxic soluble oligomers, protofibrils as well as mature fibrils. The most acceptable therapeutic strategy for the treatment of AD is to block the Aβ aggregation. Sun and co-workers have reported a decapeptide, D-enantiomeric RTHLVFFARK-NH (rk10), which acts as a potent inhibitor of Aβ aggregation and efficiently disaggregates pre-assembled Aβ fibrils.
View Article and Find Full Text PDFThe Ribosome Is the Ultimate Receptor for Trypsin Modulating Oostatic Factor (TMOF).
Biomolecules
April 2022
USDA ARS, U.S. Horticultural Research Laboratory, Subtropical Insects and Horticulture Research Unit, 2001 Rock Road, Fort Pierce, FL 34945, USA.
Trypsin Modulating Oostatic Factor (TMOF). a mosquito decapeptide that controls trypsin biosynthesis in female and larval mosquitoes. enters the gut epithelial cells of female mosquitoes using ABC-A receptor/importer.
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