AI Article Synopsis
- Maternal choline diet impacts spatial learning abilities in offspring, as shown in the study using the Morris swimming test.
- Adult rats whose mothers received a methyl-containing supplement during pregnancy and lactation took longer to find the hidden platform and spent more time near the vessel walls, indicating poorer learning.
- The observed changes in search strategies weren't linked to increased anxiety levels in male rats, suggesting that the maternal diet may influence the expression of genes related to nervous system development.
Article Abstract
Maternal choline diet is known to affect the processes of spatial learning. We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation. Increases in the time taken to find the invisible platform and the duration of swimming close to the vessel walls were seen, these demonstrating worsening of learning ability in response to the maternal diet. Changes in the platform search strategy were not associated with increases in anxiety in male rats. The possible role of a maternal methyl-containing diet in altering the expression of genes controlling the development of the nervous system is discussed.
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| http://dx.doi.org/10.1007/s11055-007-0030-7 | DOI Listing |
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