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Department of Pediatrics, Guangdong Provincial People's Hospital, The Second School of Clinical Medicine, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, 510080, China.

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Intravascular large B-cell lymphoma (IVLBL) poses a diagnostic challenge due to its varied, nonspecific symptoms. Utilizing PET-CT can be valuable in identifying lesions across the body, aiding clinicians in targeted biopsy planning. Clinicians need to be aware that IVLBL may manifest hepatic lesions along Glisson's sheath mimicking intrahepatic cholangiocarcinoma.

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