AI Article Synopsis
- Metastasis in gastric cancer is a serious complication, and researchers are investigating how certain proteins related to metastasis behave in primary versus metastatic tumors.
- They constructed tissue microarrays to compare the protein expression of genes like nm23, KISS1, KAI1, and p53 in primary tumors with those found in lymph node and liver metastases.
- The findings showed that proteins nm23, KISS1, and KAI1 had reduced expression in metastatic tissues, while p53 showed increased expression, indicating that the decline in these suppressor genes may influence how effectively the cancer spreads.
Article Abstract
Purpose: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency of the metastatic process. To compare protein expression of metastasis-related genes (nm23, KISS1, KAI1 and p53) between primary tumours and metastatic tumours may be useful in illustrating these theories.
Methods: Metastasis-related tissue microarrays (including normal tissues, primary tumours, nodal metastases and liver metastases) were constructed. The protein expression of nm23, KISS1, KAI1 and p53 in lymph node and liver metastases from advanced gastric cancer specimens was mainly examined by immunohistochemical staining in relation to primary tumours.
Results: Immunohistochemical staining showed reduced protein expression of nm23, KISS1 and KAI1 in lymph node and liver metastases compared with primary tumours. Results for p53 were to the contrary.
Conclusions: Our investigations revealed a tendency of reduced protein expression of metastasis suppressor genes nm23, KISS1 and KAI1 in gastric cancer with the progress of metastasis. This means that the progression theory is an important determinant of metastatic efficiency.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517304 | PMC |
| http://dx.doi.org/10.1111/j.1365-2613.2006.00510.x | DOI Listing |
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