In sexual health surveys, premature ejaculation (PE) is frequently the most common condition reported by men. Men with symptoms of PE often report a significant impact of the condition on their lives, experiencing personal distress and interpersonal difficulty related to their condition. Unfortunately, PE is highly ignored by the patients and the healthcare community. Most of the men do not seek medical treatment for their PE. Survey data indicate that men are reluctant to discuss sexual issues with physicians and that the physicians generally do not initiate discussions of such issues. The aim of this article was to discuss the prevalence of this condition and the impact that it has on the patient as well as on the partner. We will address the characteristics of PE, discuss interview techniques to identify the condition, and outline ways to differentiate PE from erectile dysfunction. It is our conclusion that the recognition and diagnosis of sexual dysfunctions may subsequently lead to treatment opportunities, which, in turn, may improve the quality of life for patients with such disorders.
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http://dx.doi.org/10.1111/j.1742-1241.2007.01337.x | DOI Listing |
Toxics
January 2025
Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China.
Background: The effect of the long-term persistently elevated air pollutants, often referred to as air pollution waves, on sexual function has not been sufficiently addressed.
Methods: This nationwide cross-sectional study involved 12,157 participants, with 5496 females and 5039 males. PM waves were characterized by daily average PM concentrations surpassing Grade II thresholds of China's ambient air quality standards (PM > 75 μg/m, PM > 150 μg/m) for three or more consecutive days (3-8 days).
Asian J Androl
January 2025
Department of Urology, Biruni University, İstanbul 34015, Türkiye.
Domest Anim Endocrinol
January 2025
BIOFITER-IUCA, Universidad de Zaragoza, Facultad de Veterinaria, Miguel Servet 177, 50013 Zaragoza, Spain. Electronic address:
This review presents recent findings on the effect of melatonin on ram spermatozoa. This hormone regulates seasonal reproduction in the ovine species through the hypothalamic-pituitary-gonadal axis, but it also exerts direct effects on spermatogenesis, seminal quality and fertility. In the testis, melatonin stimulates blood flow to this organ, but it also appears to be involved in the differentiation of spermatogonial stem cells and the secretion of testosterone through the MT1 and MT2 receptors.
View Article and Find Full Text PDFDrug Deliv Transl Res
January 2025
Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410006, Hunan, China.
Dapoxetine hydrochloride tablets are the most commonly used drug for the treatment of premature ejaculation (PE). However, the tablets must be taken with water 1-3 h before sexual activity, which makes the medication intake conspicuous and inconvenient. This study aimed to develop taste-masked orodispersible films (ODFs) of dapoxetine hydrochloride using ion exchange resins.
View Article and Find Full Text PDFAAPS PharmSciTech
January 2025
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Assiut University, Assiut, Egypt.
The present work focuses on the production of sildenafil co-evaporates loaded emulgels as topical dosage forms for the treatment of premature ejaculation and erectile dysfunction. Topical administration of sildenafil citrate (SILD) co-evaporates is expected to improve the bioavailability profile of the drug and to avoid the severe side effects accompanying the traditional SILD dosage forms, especially for prohibited cardiovascular cases. Firstly, the solubility of SILD was improved via solid dispersion via co-evaporation technique using PEG-5KDa and PVP-K90 as hydrophilic carriers.
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