This prospective longitudinal 15-year multifollow-up research studied whether unmedicated patients with schizophrenia can function as well as schizophrenia patients on antipsychotic medications. If so, can differences in premorbid characteristics and personality factors account for this? One hundred and forty-five patients, including 64 with schizophrenia, were evaluated on premorbid variables, assessed prospectively at index hospitalization, and then followed up 5 times over 15 years. At each follow-up, patients were compared on symptoms and global outcome. A larger percent of schizophrenia patients not on antipsychotics showed periods of recovery and better global functioning (p < .001). The longitudinal data identify a subgroup of schizophrenia patients who do not immediately relapse while off antipsychotics and experience intervals of recovery. Their more favorable outcome is associated with internal characteristics of the patients, including better premorbid developmental achievements, favorable personality and attitudinal approaches, less vulnerability, greater resilience, and favorable prognostic factors. The current longitudinal data suggest not all schizophrenia patients need to use antipsychotic medications continuously throughout their lives.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/01.nmd.0000253783.32338.6e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-order network degree revealed shared and distinct features among schizophrenia, bipolar disorder and ADHD.
Neuroscience
January 2025
School of Aerospace Engineering, Xi'an Jiaotong University, Xi'an, China; State Key Laboratory for Strength and Vibration of Mechanical Structures, Xi'an, China; National Demonstration Center for Experimental Mechanics Education, Xi'an Jiaotong University, Xi'an, China. Electronic address:
Schizophrenia (SCHZ), bipolar disorder (BD), and attention-deficit/hyperactivity disorder (ADHD) share clinical symptoms and risk genes, but the shared and distinct neural dynamic mechanisms remain inadequately understood. Degree is a fundamental and important graph measure in network neuroscience, and we here extended the degree to hierarchical levels based on eigenmodes and compared the resting-state brain networks of three disorders and healthy controls (HC). First, compared to HC, SCHZ and BD patients exhibited substantially overlapped abnormalities in brain networks, wherein BD patients displayed more significant alterations.
View Article and Find Full Text PDFPreventing disease progression in schizophrenia: What are we waiting for.
J Psychiatr Res
December 2024
Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.
Despite research advances and progress in health care, schizophrenia remains a debilitating and costly disease. Onset occurs typically during youth and can lead to a relapsing and ultimately chronic course with persistent symptoms and functional impairment if not promptly and properly treated. Consequently, over time, schizophrenia causes substantial distress and disability for patients, their families and accrues to a collective burden to society.
View Article and Find Full Text PDFPatients with severe mental illness in the general emergency department: Clinical characteristics, quality of care and challenges.
Gen Hosp Psychiatry
December 2024
Geha Mental Health Center, Petach Tikva, Israel; Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Background: Morbidity and mortality rates are notably higher among individuals with severe mental illnesses (SMI). People with SMI often have lower access to healthcare services, and the medical care they receive is known to be suboptimal. Consequently, treatment in an acute care setting rather than a community setting is more common.
View Article and Find Full Text PDFMental Health Services for Serious Mental Illness: Scoping Review of Randomised Controlled Trials.
Nurs Open
January 2025
Institute of General Practice, Medical Faculty of the Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
Aims: This review aims to classify the evidence from randomised controlled trials (RCTs) on mental health services (MHS) for people with serious mental illness (SMI) available in the Cochrane Schizophrenia Group's (CSzG) specialised register.
Design: Scoping review.
Methods: We retrieved and screened RCTs of service-level interventions considering non-pharmacological approaches for mental healthcare of the CSzG register.
Initiation of Psychotropic Drugs in Spouses of Patients With Early-Onset Alzheimer's Disease: A Matched Cohort Study.
Int J Geriatr Psychiatry
January 2025
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
Objectives: The diagnosis of early-onset Alzheimer's disease (EOAD) can cause emotional stress not only to the patients themselves but also to their spouses. This study aimed to evaluate the risk of psychiatric disorders in spouses of EOAD patients, using psychotropic drug initiation as a surrogate indicator.
Methods: A cohort study was conducted using a Japanese claims database, with spouses of EOAD patients (exposed spouses) matched with spouses of non-EOAD individuals (reference spouses) up to a 1:10 ratio.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!