[Relevance of the toxoplasma IgG avidity test in the serological surveillance of pregnant women].

Ann Biol Clin (Paris)

Service de parasitologie-mycologie, CHRU de Lille - Faculté de Médecine, Université de Lille 2, and Clinique de gynécologie et obstétrique, Hôpital Jeanne de Flandre, France.

Published: October 2007

In addition to the serological systematic screening tests, kits to measure the avidity of toxoplasma IgG antibodies are currently available. Since high-avidity IgG toxoplasma antibodies have been shown to exclude recent infection, IgG avidity determination is especially useful in ruling out acute infection having occurred in the 3-4 prior months of pregnancy. We therefore compared the efficacy of two toxoplasma IgG avidity ELISA kits: SFRI (SFRI Laboratoire) and VIDAS Toxo-IgG avidity kit (bioMérieux). The agreement of the results from the 2 commercial assays were analysed using 55 serum samples, in terms of global mother-child Toxoplasma results and outcome, specially with light of the results of Toxoplasma antenatal, postnatal assays and of clinical follow up of children.

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