The ability of the weak inorganic acids (H2S, HCN) and lower carboxylic acids to interact with bilayer lipid membranes (BLMs), change their conductivity, act as the protonophores were investigated. The mechanism of the BLM conductivity change was studied. The factors affecting the acids interaction with model lipid membranes were determined. Maximum conductivity change observes at pH equal dissociation constant of weak acids and depends on the distribution coefficient "octanol(membrane)-water".
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