AI Article Synopsis
- L-DOPA-induced dyskinesia (LID) is a significant challenge for Parkinson's disease patients using L-DOPA long-term.
- A novel aphakia mouse model, which simulates Parkinson's disease, shows that chronic L-DOPA treatment leads to abnormal movements triggered by dopamine receptor agonists, while antidyskinetic agents help reduce these movements.
- The study also found changes in gene expression related to dyskinesia, specifically increased FosB levels in brain regions not previously focused on in LID research, making the aphakia mouse a valuable tool for further understanding and treating LID.
Article Abstract
L-DOPA-induced dyskinesia (LID) is one of the main limitations of long term L-DOPA use in Parkinson's disease (PD) patients. We show that chronic L-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit mimicking PD. The stereotypical abnormal involuntary movements were induced by dopamine receptor agonists and attenuated by antidyskinetic agents. The development of LID was accompanied by preprodynorphin and preproenkephalin expression changes in the denervated dorsal striatum. Increased FosB-expression was also noted in the dorsal striatum. In addition, FosB expression was noted in the pedunculopontine nucleus and the zona incerta, structures previously not examined in the setting of LID. The aphakia mouse is a novel genetic model with behavioral and biochemical characteristics consistent with those of PD dyskinesia and provides a more consistent, convenient, and physiologic model than toxic lesion models to study the mechanism of LID and to test therapeutic approaches for LID.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570533 | PMC |
| http://dx.doi.org/10.1016/j.nbd.2007.03.013 | DOI Listing |
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