AI Article Synopsis
- Researchers discovered that certain alpha-glucosidase inhibitors, based on thalidomide structures, can block liver X receptors (LXR).
- New LXR antagonists were created by modifying the structure of these glucosidase inhibitors.
- The new antagonists feature a 2'-substituted phenylphthalimide structure, highlighting innovative structural development in this area.
Article Abstract
Alpha-glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2'-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
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| http://dx.doi.org/10.1016/j.bmcl.2007.04.090 | DOI Listing |
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