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Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review.
Cardiovasc Diabetol
December 2024
INSERMU1138-Centre de Recherche Des Cordeliers, Paris Cite University, Sorbonne University, 75006, Paris, France.
Article Synopsis
- Diabetic nephropathy is closely linked to persistent high blood sugar levels, resulting in both kidney and heart vascular issues, particularly in type 1 diabetes, where genetics play a significant role in risk.
- Extensive research, including genome-wide association studies (GWAS), has identified the angiotensin I-converting enzyme (ACE) gene as a major factor in susceptibility and prognosis for diabetic nephropathy.
- Despite various studies identifying genetic variants like ACE I/D polymorphism and others, no major gene has been conclusively linked, and the effects observed remain relatively modest.
Association of Gene Polymorphisms with Polycystic Ovary Syndrome: A Meta-analysis.
Gynecol Minim Invasive Ther
September 2024
Human Cytogenetics and Genomics Laboratory, Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Objectives: Polycystic ovary syndrome (PCOS) is a prevalent endocrine-metabolic disorder affecting reproductive-aged women. Genetic factors play a significant role in its development. This meta-analysis assesses the associations between specific gene polymorphisms (Vitamin D receptor [VDR] and adiponectin [ADIPOQ]) and PCOS susceptibility.
View Article and Find Full Text PDFAnalysis of metabolites associated with ADIPOQ genotypes in individuals with type 2 diabetes mellitus.
Sci Rep
November 2024
Department of Molecular Biology/CCEN, Federal University of Paraiba (UFPB), Joao Pessoa, PB, Brazil.
Diabetes mellitus (DM) is a significant public health problem and it is known that the identification of molecular markers involved in glycemic control can impact disease control. Although the rs266729 polymorphism located in the promoter of the adiponectin gene (ADP) has been shown to be a candidate for involvement in glycemic control, the genotypic groups have never been characterized in terms of metabolomic aspects. Objective: Analyze the metabolites present in the rs266729 genotype groups.
View Article and Find Full Text PDFACVR2B polymorphism, Adiponectin, and GDF-15 levels as biomarkers for cachexia in gastrointestinal cancer.
Sci Rep
November 2024
Biotechnology Unit, University of Ribeirão Preto (UNAERP), Ribeirão Preto, 14096-900, Brazil.
Reversing cancer cachexia remains a challenge. Genetic biomarkers for the early detection of the disease have been explored in order to enable the implementation of preventive measures. We therefore genotyped candidate genes based on cachexia phenotype and quantified adiponectin and GDF-15 levels in cachectic patients with gastrointestinal cancer.
View Article and Find Full Text PDFAssociation of lipid levels, adipokines and multiple myeloma: a two-sample multivariate Mendelian randomization study.
Sci Rep
October 2024
First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250000, China.
Article Synopsis
- * Two types of analyses (two-sample and multivariate Mendelian randomization) were conducted to determine if there's a causal relationship between these factors and MM.
- * The findings showed no strong causal link between lipid levels, adipokines, and the risk of MM, but suggested the potential for a weak association, indicating that more research is needed to explore the underlying mechanisms.
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