AI Article Synopsis

  • MicroRNAs (miRNAs) are small regulatory RNAs that influence gene expression and have been shown to play significant roles in muscle development.
  • The study focuses on miRNAs in cardiac hypertrophy, revealing that their expression changes in hypertrophic hearts and cells.
  • Inhibiting specific miRNAs (miR-21 and miR-18b) promotes heart growth, while introducing them reduces hypertrophy, highlighting their importance in cardiac regulation.

Article Abstract

MicroRNAs (miRNAs) are a recently discovered class of approximately 22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and miR-133 play an important role in modulating muscle proliferation and differentiation. Here, we investigate the involvement of miRNAs in cardiac hypertrophy. We analyzed the global expression of miRNAs in agonist-induced hypertrophic cardiomyocytes as well as in pressure overload-induced hypertrophic hearts and found the miRNA expression profile altered in those hypertrophic conditions. We further show that inhibition of endogenous miR-21 or miR-18b augments hypertrophic growth. Conversely, introduction of functional miR-21 or miR-18b into cardiomyocytes represses myocyte hypertrophy. Together, our studies point to miRNAs as critical regulators of cardiac hypertrophy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934409PMC
http://dx.doi.org/10.1016/j.yjmcc.2007.04.004DOI Listing

Publication Analysis

Top Keywords

cardiac hypertrophy
8
mir-21 mir-18b
8
mirnas
5
expression
4
expression micrornas
4
micrornas dynamically
4
dynamically regulated
4
regulated cardiomyocyte
4
hypertrophy
4
cardiomyocyte hypertrophy
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!