Generalized purpuric lichen nitidus is an extremely rare form of lichen nitidus. We present the third documented case of this uncommon dermatosis, which was treated successfully with orally administered cyclosporine. During a 12-month follow-up after the cessation of the drug, no recurrence was noticed.
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Article Synopsis
- Perforating lichen nitidus is a rare skin condition, with only about 11 cases documented globally, usually affecting young males in areas that experience frequent mechanical irritation like hands and elbows.
- The condition features distinct histopathological characteristics, including a specific lymphohistiocytic inflammation within the skin layers, leading to the elimination of dermal materials through the skin surface.
- This case study is notable as it describes the first instance of perforating lichen nitidus in a patient with atopic dermatitis undergoing dupilumab treatment, indicating that while atopic dermatitis improved, the lichen nitidus worsened, hinting at a unique underlying mechanism for the condition.
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