AI Article Synopsis
- * In our study, which involved 2,900 obese individuals and 5,100 controls, we reported a very significant result with a P value of 1.67 x 10(-26).
- * The identified genetic variation accounts for about 22% of the risk for common obesity, suggesting that FTO could be an important focus for future research on obesity treatment and understanding.
Article Abstract
We identified a set of SNPs in the first intron of the FTO (fat mass and obesity associated) gene on chromosome 16q12.2 that is consistently strongly associated with early-onset and severe obesity in both adults and children of European ancestry with an experiment-wise P value of 1.67 x 10(-26) in 2,900 affected individuals and 5,100 controls. The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses.
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| http://dx.doi.org/10.1038/ng2048 | DOI Listing |
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