Objective: To compare the speech perception performance of older adults with that of adult cochlear implant (CI) recipients in a single center in Hong Kong.
Design: A retrospective study of 14 older adult CI users (age at operation, 56 to 77 yr old) and 14 adults (age at operation, 18 to 53 yr old) who received CIs and were matched for duration of profound deafness. The outcome indicator of their performance includes ratings of 0 to 7 on the speech perception category (SPC), which is based on their speech perception test scores at 6, 12, and 24 mo after implantation. Statistical analyses were used to compare SPC ratings between the two groups at the tested intervals. Results of specific speech perception tests between the two groups were also analyzed at the tested intervals, along with the rate of improvement of the specific tasks from 0 to 6 mo, 0 to 12 mo, and 0 to 24 mo postoperatively. Multiple regression analysis was used to assess which variables would independently predict the outcome performance of CIs.
Results: There were no significant differences (p = 0.228 to 0.724) between the SPC ratings of the adult group and the older adult group at the tested intervals. The adult group scored significantly better in the postoperative 0- to 6-mo improvement rate (p = 0.047) in open-set sentence recognition, but the improvement decelerated so that it was comparable with that of the older adult group by 12 mo after implantation. The adult group also scored significantly better (p = 0.031) in tone identification at 24 mo after implantation compared with the older adult group. The majority of the speech perception task scores, and rates of improvement were comparable between the older adult group and the adult group at the tested time intervals. Multiple regression analysis revealed a significant relationship (p = 0.025) between the outcome indicator of everyday sentence recognition at 12 mo after implantation and the outcome predictor of duration of profound deafness. However, the goodness of fit (r) of this model was 0.11, suggesting that only 11% of the variance in 12-mo postoperative everyday sentence recognition was explained by duration of profound deafness, leaving a large proportion of unexplained variance.
Conclusion: : The overall performance of the older adult CI recipients is comparable with that of the adult group. Duration of profound deafness, irrespective of age, is accountable for a small part of the outcome. Because older adults as well as younger adults can benefit from CIs, age should not be the predominant factor for declining CIs among older adults.
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http://dx.doi.org/10.1097/AUD.0b013e318031509d | DOI Listing |
Sleep
January 2025
UR2NF-Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN - Centre for Research in Cognition and Neurosciences and UNI - ULB Neuroscience Institute, Université Libre de Bruxelles (ULB), Brussels, Belgium.
Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted Memory Reactivation (TMR), involving cueing learned material during post-training sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and post-training sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during post-training sleep affects performance gains and delayed microstructural remodeling, using both standard Diffusion Tensor Imaging (DTI) and advanced Neurite Orientation Dispersion & Density Imaging (NODDI).
View Article and Find Full Text PDFHernia
January 2025
Department of Surgery, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1259, New York, NY, 10029, USA.
Purpose: While surgeons agree that perioperative field blocks should be performed for open inguinal hernia surgery, there lacks consensus in the minimally invasive context. Prior small-scale randomized trials study pain scores only up to 24 h postoperatively. Thus, we sought to investigate the analgesic benefits of a bupivacaine transversus abdominis plane (TAP) block in the first 4 postoperative days.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
January 2025
Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, 17489, Greifswald, Germany.
Introduction: The objective of this study is to compare the 5 year overall survival of patients with stage I-III colon cancer treated by laparoscopic colectomy versus open colectomy.
Methods: Using Mecklenburg-Western Pomerania Cancer Registry data from 2008 to 2018, we will emulate a phase III, multicenter, open-label, two-parallel-arm hypothetical target trial in adult patients with stage I-III colon cancer who received laparoscopic or open colectomy as an elective treatment. An inverse-probability weighted Royston‒Parmar parametric survival model (RPpsm) will be used to estimate the hazard ratio of laparoscopic versus open surgery after confounding factors are balanced between the two treatment arms.
Clin Pharmacokinet
January 2025
Clinical Pharmacology and Toxicology Service, Anesthesiology, Pharmacology and Intensive Care Department, Geneva University Hospitals, 4 Rue Gabrielle Perret-Gentil, 1205, Geneva, Switzerland.
Background And Objective: Fexofenadine is commonly used as a probe substrate to assess P-glycoprotein (Pgp) activity. While its use in healthy volunteers is well documented, data in older adult and polymorbid patients are lacking. Age- and disease-related physiological changes are expected to affect the pharmacokinetics of fexofenadine.
View Article and Find Full Text PDFEur J Pediatr
January 2025
Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Faculty of Health Sciences, Universidad de Zaragoza, Instituto de Investigación Sanitaria de Aragón (IIS Aragón), 50009, Saragossa, Spain.
Unlabelled: Most of the available tools to assess adherence to Mediterranean diet (MedDiet) were constructed for adults, having limited applicability to children and adolescents. The aim of this study is to validate a specific questionnaire to assess adherence to MedDiet in children aged 3 to 6 years (MED4CHILD questionnaire). The validation was performed in a baseline examination of a cohort of children who were recruited in schools in seven cities.
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